BACKGROUND The aim was to determine distribution and trends in the outpatient utilization of antipsychotics to evaluate the rationality of antipsychotic drug prescribing during the ten year period. SUBJECTS AND METHODS The epidemiological method of descriptive and analytical observation was used. Data on drug utilization from Zagreb Municipal Pharmacy were used to calculate the number of defi...

OBJECTIVES To determine the therapeutic equivalence and safety of once daily (OD) versus three times daily (TID) dosing of a total daily dose of 3 g Salofalk (mesalazine) granules in patients with active ulcerative colitis. DESIGN A randomised, double-blind, double-dummy, parallel group, multicentre, international, phase III non-inferiority study. SETTING 54 centres in 13 countries. PATIE...

We investigated the contributions of Tyrp1 and Gpnmb to the iris transillumination defect (TID) in five age cohorts of BXD mice. Using systems genetics, we also evaluated the role of other known pigmentation genes (PGs). Mapping studies indicate that Tyrp1 contributes to the phenotype at all ages, yet the TID maps to Gpnmb only in the oldest cohort. Composite interval mapping reveals secondary ...

We report the results of our ionospheric HF heating experiments to generate artificial acoustic-gravitywaves (AGW) and traveling ionospheric disturbances (TID),whichwere conducted at theHigh-frequencyActiveAuroral Research Program facility inGakona, Alaska. Based on the data from UHF radar, GPS total electron content, and ionosonde measurements, we found that artificialAGW/TID can be generated ...

We characterize the TID resilience and annealing response of high-density SRAMs, fabricated in 90 nm commercial processes. Results demonstrate intrinsic SRAM hardness at 300 krad(Si), but also reveal several orders of magnitude increase in leakage current at 1 Mrad(Si) of exposure, with recorded critical functionality failures. However, the technology is shown to be very responsive to temperatu...

The aim was to estimate outpatient consumption of psychotropic drugs in Croatia in correlation with Scandinavian countries. Data on drug utilization, from Zagreb Municipal Pharmacy, were used to calculate the number of defined daily doses (DDD) and DDD per 1000 inhabitants per day (DDD/TID) using Anatomical-Therapeutic-Chemical methodology (ATC) by WHO. Data of the Nordic Medico-Statistical Com...

Total ionizing dose (TID) effects and single event effects (SEE) in antifuse-, Flash-, and SRAM-based field programmable gate arrays (FPGAs) are reviewed. There is a brief discussion of the programmable element impact on the FPGA architecture. In the following sections, most radiation data are from antifuse-based FPGAs. The basic TID mechanisms are introduced and used to explain the anomalies i...