Spontaneous thyroid tumors in salmonid fishes, which appear to originate as simple hyperplasias, according to Marine and Lenhart (10, 11) and Marine (9), ultimately become invasive and re place fibrous connective tissue, muscle, and bone. Upon treatment with iodine these tumors will regress even after they have become invasive. It is interesting to compare the tumor in fish with thyroidal growt...

The article reviews the controversial area of poorly differentiated thyroid carcinoma. Consensus criteria that define poorly differentiated thyroid carcinoma have been published in 2007. According to these, poorly differentiated thyroid carcinoma is a distinct histotype and the term "poorly differentiated" should not be used as a synonym for high-grade thyroid cancer. Data in the literature sho...

Thyroid carcinoma, the most common malignant tumors in the thyroid, originates from thyroid epithelial cells. In recent years, the incidence of thyroid carcinoma is on the rise. It has become one of the malignant solid tumors with the fast growth rate in almost two decades (Cramer et al., 2010). At current, comprehensive treatment dominated by surgery is a major way to treat thyroid carcinoma. ...

Human endocrine tumors often express the somatostatin receptors SSTR 1-5 with different intensity. It has been widely investigated their distribution in pituitary adenomas, brain tumors, adrenal tumors and neuroendocrine tumors in gastrointestinal tract (NET). Some of studies also concern the expression of SSTRs in thyroid tumors but they are mainly limited to parafollicular C cells - derived m...

We have recently reported the activation of a new oncogene in human papillary thyroid carcinomas. This oncogene, papillary thyroid carcinoma (PTC), is a novel rearranged version of the ret tyrosine-kinase protooncogene. Thyroid neoplasms include a broad spectrum of malignant tumors, ranging from well-differentiated tumors to undifferentiated anaplastic carcinomas. To determine the frequency of ...

Heterotrimenc G proteins participate in the signal transduction ens cade. Adult thyroid tumors have been shown to harbor specific point mutations in codons 201 and 227 of the G@asubunit of the adenylate cyclase stimulator. This protein affects the GDP/GTP turnover and finally results in an enhanced activation of G@and thus adenylate cyclase. We attempted to find out if G@agene mutations were pr...

Tumors of parafollicular cells and nonepithelial tumors occur less frequently than tumors derived from follicular cells. This review summarizes the histologic and cytologic features of these neoplasms and the nonneoplastic diseases that often have to be included in the differential diagnosis of thyroid tumors. Also, the role of fine-needle aspiration biopsy and frozen section interpretation in ...

Collision tumor represents the proximal coexistence of two histologically distinct tumors. The combination different types tumors in a single thyroid gland is extremely unusual. We reported case follicular carcinoma and papillary microcarcinoma occur independently as primary separated by normal tissue 59- year- old Saudi female, presented at clinic with goiter for months duration without sympto...

The molecular etiology of follicular thyroid tumors is largely unknown, rendering the diagnostics of these tumors challenging. The somatic alterations present in these tumors apart from RAS gene mutations and PAX8/PPARG translocations are not well described. To evaluate the profile of somatic alteration in follicular thyroid tumors, a total of 82 thyroid tissue samples derived from 48 patients ...