We investigated the effect of thyroid hormone on phosphatidylinositol-specific phospholipase C activity in rat liver. Thyroidectomy increased the activity of the enzyme. Thyroid hormone (T4, 40 micrograms) administration to thyroidectomized-rats decreased phospholipase C activity. The inhibition induced by thyroid hormone was of a non-competitive type. The higher concentration of Ca2+ strongly ...

In teleosts, the thyroid gland is mostly found in the subpharyngeal region. However, in several species thyroid follicles are found in, for example, heart, head kidney and kidney. Such heterotopic thyroid follicles are active, and considered to work in concert with the subpharyngeal thyroid. In Mozambique tilapia (Oreochromis mossambicus) thyroid activity is, indeed, restricted to the subpharyn...

2014 Aim: The aim of this study was to determine the relationship between thyroid disorders and prolactin in patients with and without lupus activity. Patients & methods: Women with systemic lupus erythematosus (SLE) were evaluated for lupus activity. Serum tri-iodothyronine (T3), serum thyroxine (T4) and thyroid-stimulating hormone (TSH), anti-thyroid peroxidase (anti-TPO) anti-thyroglobulin (...

G protein-coupled receptors (GPCRs) are involved in the pathophysiology of a wide range of diseases and constitute an attractive therapeutic target. In the thyroid gland, TSH receptor (TSHR), a member of the GPCR family, is a major regulator of thyroid differentiation and function. Alterations in TSHR activity are often involved in the development of pathologies such as thyroid cancer and thyro...

Because human erythrocyte membrane Ca2+-ATPase is a calmodulin-dependent enzyme, and because physiological levels of thyroid hormone stimulate this enzyme system in vitro, we have studied the role of calmodulin in this model of extranuclear thyroid hormone action. Ca2+-ATPase activity in the absence of thyroid hormone ("basal activity") was increased by inclusion in the preassay incubation mixt...

in 30 patient with single cold thyroid nodule and normal thyroid function tests, 99mtc-mibi scan is performed. the nodules are divided to hot (10), warm (12) and cold (8). fna reported papillary ca in 4, suspicious follicular neoplasm in 3 and 23 benign lesions. 7 patients were operated on and had final pathology reports (4 papillary ca and 3 benign lesions). all the nodules with no mibi uptake...