background ascorbic acid is amongst important water-soluble vitamins and when used orally in high-doses it has been observed to relieve pain and reduce opioid use in patients. however no controlled trial has compared the antinociceptive effects of ascorbic acid with other analgesic groups on animal models, and investigated the involved mechanisms. objectives in the present study, the antinocice...

Background: Animals have an internal biological clock with melatonin hormone that helps them to adapt to light/dark circles. Since melatonin is associated with an alteration in the expression and production of opioid receptors, this study aimed to evaluate the effect of changes in the light/dark circles on pain sensation in rats. Methods: This research study in order to investigate the thermal...

background cisplatin is an effective antineoplastic drug used extensively in the treatment of malignancies. it induces painful peripheral neuropathy at high doses. objectives the aim of this study was to investigate the effect of carbamazepine (cbz) on cisplatin-induced peripheral neuropathic pain by using the tail-flick test. materials and methods the study was performed using male wistar rats...

conclusions it looks that a. hirtifolium has antinociceptive effects that might be due to flavonoids and saponins in plant the analgesic effect of which was demonstrated previously. results allium hirtifolium extract at (200 mg/kg dosage), alone and in combination with aspirin, had shown antinociceptive effect in writhing, tail-flick, and formalin tests (p < 0.01). allium hirtifolium extract (a...

The seeds of Peganum harmala L. (Pgh) (Zygophyllaceae) have been used in Moroccan traditional medicine to treat various diseases. The objective of this study was to investigate the analgesic effect of ethyl acetate (EAE), butanolic (BE) and aqueous (AqE) extracts of seeds of Peganum harmala and to elucidate the possible action mechanism of each extract. The antinociceptive action was assayed in...

extracts obtained from the aerial parts of stachys lavandulifolia (lamiaceae) are used in iranian folk medicine as remedies for the treatment of various painful and inflammatory diseases. for evaluation of its probable analgesic and anti-inflammatory effects, hydroalcoholic, polyphenolic and boiled extracts of the aerial parts of the herb were prepared and their analgesic effects were studied i...

In the traditional medicine, Taxus baccata Linn. has been used as analgesic, anticonvulsant, and antiinflammatory remedy. In the present study, bark of plant was extracted with 95% ethanol and ether at room temperature and evaluate for their analgesic activity in mice using the tail-flick and acetic acid-induced writhing method. Ether extract exhibits potent analgesic activity in tail-flick tes...

This study investigated the antinociceptive mechanisms of khat extract (100, 200, and 400 mg/kg, i.p.) in four pain models: two thermic (hot plate, tail-flick) and two chemical (acetic acid, formalin) models. Male mice were pretreated intraperitoneally (i.p.) with the opioid receptor blocker naloxone (5 mg/kg), the cholinergic antagonist atropine (2 mg/kg), the selective α1 blocker prazosin (1 ...

Background &#x0D; Ficus religiosa, commonly known as peepal, is widely distributed in Indian subcontinent. It has been used an antiepileptic, aphrodisiac, analgesic, anti-inflammatory and laxative traditional medicine.&#x0D; Objective To explore the analgesic effect of aqueous root extract religiosa using thermal chemical models pain swiss albino mice.&#x0D; Method The aerial was prepared soxhl...