PURPOSE Thymol and carvacrol, two main components of thyme, have shown anti-inflammatory effects. The aim of this study was to assess the effects of these components on Jurkat leukemia cells as an in vitro T cell model and their molecular mechanisms of activity. METHODS Cells were cultured in the presence of components and subsequently stimulated with phorbol-12-myristate-13-acetate (PMA)/cal...

Background: Several pharmacological effects have been attributed to thymol. However, limitations such as low solubility in water, bioavailability, and high volatility limited its use. Objectives: The present study aimed prepare characterize thymol-loaded solid lipid nanoparticles (SLNs) improve the efficacy of Methods: Thymol-loaded SLNs were characterized by atomic force microscopy (AFM), diff...

Replacement of barbiturate buffer by a tris-hydroxymethylaminomethane buffer in the thymol test reagent of Maclagan greatly improves the stability of the reagent. Thymol turbidity measurements made by means of the modified reagent agreed closely with those made with barbiturate-containing reagents. However in hyperlipemic sera, the latter reagent gave higher turbidities. A reaction of barbitura...

Pathogens, ammonia, odor, and greenhouse gas emissions are serious environmental concerns associated with swine production. This study was conducted in two manure pits (33,000 L each) to determine the influence of 1.5 or 3.0 g thymol L(-1) and 80 mg L(-1) urease inhibitor amendments on urea accumulation, coliform bacteria, odor, and methane emission. Each experiment lasted 18 or 19 d, during wh...

Thymol and Butylated hydroxytoluene (BHT) were tested for their ability to inhibit carbon tetrachloride (CCl4)-induced lipid peroxidation in mice liver. To achieve this purpose, four groups of mice were tested, GP I: Animals served as normal control, GP II: Animals injected i.p. with a single dose of CCl4 (0.5 ml/kg B.W), GP III and IV: Animals pretreated by oral administration of thymol or BHT...

AIM To evaluate urea hydrolysis, volatile fatty acid (VFA) production (odour) and coliforms in cattle waste slurries after a urease inhibitor N-(n-butyl) thiophosphoric triamide (NBPT) and a plant oil component (thymol) were added. METHODS AND RESULTS Faeces from cattle fed a diet of 70% corn silage and 30% alfalfa haylage, urine and distilled water in the ratio 50 : 35 : 15 were blended at h...

Thyme (Thymus vulgaris L., Lamiaceae) is an aromatic and medicinal plant that has been used in folk medicine, phytopharmaceutical preparations, food preservatives, and as an aromatic ingredient. The effect of Thymus vulgaris essential oil (TEO) and its isolated constituents thymol and cavacrol (CVL) were studied in the following experimental models: ear edema, carrageenan-induced pleurisy, and ...

AIM The biopotential of the essential oils of the Greek aromatic plants Satureja thymbra and Satureja parnassica were investigated, together with their major components carvacrol, thymol, γ-terpinene and p-cymene. MATERIALS AND METHODS Antioxidant and cancer cell cytotoxic properties were determined using 2,2-diphenyl-1-picrylhydrazyl and sulforhodamine B assays, respectively. The antiprolife...

Two new monoterpenoids, 8,10-dihydroxy-9(2)-methylbutyryloxythymol (1) and 10-hydroxy-8,9-dioxyisopropylidene-thymol (2), together with five known thymol derivatives: 8,9,10-trihydroxythymol (3), thymol-beta-glucopyranoside (4), 9-hydroxythymol (5), 8,10-dihydroxy-9-isobutyryloxythymol (6), and 8-hydroxy-9,10-diisobutyryloxythymol (7), were isolated from Centipeda minima. Their structures were ...

Nisin Z and thymol were tested, alone and in combination, for antibacterial activity against Listeria monocytogenes ATCC 7644 and Bacillus subtilis ATCC 33712. The antibacterial effect of nisin Z, produced by Lactococcus lactis KE3 isolated from the traditional Moroccan fermented milk, was greatly potentiated by sub-inhibitory concentrations of thymol in both bacterial strains. Our data showed ...