1. Jadavji T, Scheifele D, Halperin S; Canadian Paediatric Society/Health Cananda Immunization Monitoring Program. Thrombocytopenia after immunization of Canadian children, 1992 to 2001. Pediatr Infect Dis J. 2003;22:119-22. 2. Arya LS, Ghai OP, Saraya AK. Thrombocytopenic purpura following DPT vaccination. Pediatr Hematol Oncol. 1993;10:381-3. 3. Hsieh YL, Lin LH. Thrombocytopenic purpura foll...

Neonatal alloimmune thrombocytopenia should be suspected in any thrombocytopenic infant born to a healthy non-thrombocytopenic mother. Nevertheless, the condition occurs in only 1 or 2/10 000 births.' More often transient neonatal immune thrombocytopenia results from maternal idiopathic thrombocytopenic purpura. We report the coexistence of alloimmunisation and autoimmunisation against platelet...

Platelet function disorder in the presence of normal platelet count has been reported to lead variable clinical phenotypes [1]. Differential diagnosis these bleeding diathesis types much more complex than thrombocytopenic conditions.

BACKGROUND Cotton wool spots are known to be a complication in patients with thrombotic thrombocytopenic purpura or with polymyositis. CASE A 53-year-old woman developed numerous cotton wool spots around the optic disc of both eyes. OBSERVATIONS Fluorescein angiography disclosed capillary obstruction and microaneurysms in the early phase, followed by dye leakage in the late phase. Systemica...

The cause of platelet agglutination in thrombotic thrombocytopenic purpura has been an enigma. Current evidence indicates that the interaction of platelets with a platelet-aggregating factor or unusually large multimers of factor Vlllrvon Willebrand factor, or both, may cause the abnormal platelet agglutination. Recent success in the treatment of thrombotic thrombocytopenic purpura with intrave...

background: myelodysplastic syndrome is a mixed clonal disorder of bone marrow progenitor cells. understanding the pattern of the different lineage-specific, immature, and mature markers in myelodysplastic syndrome will help in setting-up the frame of reference to diagnose. patients and methods: we compared 60 bone marrow samples from 30 newly-diagnosed patients with myelodysplastic syndrome an...

BACKGROUND The etiology of thrombocytopenia during infancy and early childhood may be different from that of older children, because young children frequently receive vaccines. The following study was performed to understand whether there was a causal relationship between vaccinations and thrombocytopenia. METHODS We retrospectively studied, through chart review, the relationship between vacc...

normal 0 false false false microsoftinternetexplorer4 the association of solid tumors with idiopathic thrombocytopenic purpura (itp) is rare. however, there have been some case reports indicating an association between breast cancer and itp. in this article four patients with breast cancer and itp are mentioned. the diagnosis of breast cancer was based on the results of biopsy or surgical sampl...

conclusions: in this study, a higher rate of more severe itp in recently vaccinated young children was observed in comparison with other probable etiologies. further investigations are needed to explain this finding. results: 51 patients were enrolled in this study (mean age = 3.86 ± 1.53 months; males = 32 [62.7%]). in 33 (64.7%) patients the platelets level was below 20000 /mm3. thrombocytope...

background: the autoimmune disease known as idiopathic (immune thrombocytopenic purpura thrombocytopenic purpura (itp) is clinically defined by a low numbers of platelets in the circulation blood. this study aimed to isolate autoantibodies made against the platelet glycoproteins using platelets from healthy volunteers, to determine their specificity and further elucidate their effects on platel...