نتایج جستجو برای: thiohydantoin
تعداد نتایج: 120 فیلتر نتایج به سال:
In alkaline medium the benzil reacts with urea or thiourea in presence of base like 30% w/v NaOH, using ethanol as solvent to give the cyclic hydantoin compounds, or phenytoin (5,5’dipenylimidazolidine-2,4-dione) and thiohydantoin (5,5-diphenyl-2-thioimidazolidine-4-one) respectively. The first step in the reaction involve the attack by urea or thiourea on the carbonyl group of the benzil to gi...
The present paper describes studies on the synthesis of the antiepileptic drug phenytoin, and of structurally related derivatives. First, the influence of the solvent has been investigated in the microwave-assisted synthesis of the drug, resulting in a yield improvement and a cleaner reaction. Second, a two-step reaction is described to synthesize selectively and in high yields phenytoin. The f...
A manual high-sensitivity sequencing method is described, in which 4-NN-dimethylaminoazobenzene 4'-isothiocyanate is used for the stepwise degradation of amino acid residues from the peptides. The 4-NN-dimethylaminoazobenzene 4'-thiazolinones of amino acids that were released, after conversion into their thiohydantoin derivatives, were identified by t.l.c. on polyamide sheets. This new method i...
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