Alpha Lipoic Acid, or thioctic acid, is a sulfur-containing fatty acid compound that acts as a coenzyme and an antioxidant. It is called a “universal antioxidant” because of its potent ability to neutralize a wide range of free radicals. Recent studies suggest that alpha lipoic acid may improve situations in the body involving free radicals, such as heart disease and cancer, and other disorders...

The thioctic acid amides of 2'-aminoethyl alpha-d-mannopyranoside and 2'-aminoethyl alpha-1,3-d-mannopyranosyl (alpha-1,6-d-mannopyranosyl)-alpha-d-mannopyranoside presented on both planar and nanoparticle gold surfaces give higher specific and lower non-specific protein binding than the related 2'-thioethyl glycosides.

Introduction Alpha-lipoic acid (ALA – also known as thioctic acid) was discovered in 1951 as a molecule that assists in acyl-group transfer and as a coenzyme in the Krebs cycle. In the 1980s, the scientific community realized alpha-lipoic acid is a powerful antioxidant. Several qualities distinguish alpha-lipoic acid from other antioxidants: ALA can be synthesized by animals and humans;1 it neu...

Stokstad and Pierce (1952) presented evidence that protogen revers the inhibition of propionate for Streptococcus faecalis. IAter Brockman et al. (1952) determined the structure of protogen. Bullock et al. (1952) synthesized protogen and various closely related compounds having the property of reversing the inhibition of propionate for S. faecalis and suggested the general name, thioctic acid, ...