Understanding the molecular mechanisms of neurological disorders is necessary for development personalized medicine. When diagnosis considers not only disease symptoms, but also their basis, treatments tailored to individual patients may be suggested. Vitamin-responsive are induced by deficiencies in vitamin-dependent processes. These occur due genetic impairments proteins whose functions invol...

Vitamin B1 (thiamine) plays an important role in various metabolic processes and is one of the main factors body's health. Thiamine excess deficiency body might cause a variety diseases such as shortness breath, beriberi, heart failure, hence thiamine levels must be detected reference for intake. The present research using amperometric biosensor method yeast Saccharomyces cerevisiae bioreceptor...

Edith Heinrich and Nikola Getoff* Institute for Theoretical Chemistry and Structural Biology as well as Ludwig Boltzmann Institute for Radiation Chemistry and Radiation Biology, The University of Vienna, Althanstr.14, A-1090 Vienna, Austria. Fax: ++43(1)-4277-52795. E-mail: [email protected] * Author for correspondence and reprint requests Z. Naturforsch. 58c, 244Ð248 (2003); received ...

The relationship of vitamin Br to carbohydrate metabolism was one of the earliest functions of a vitamin to be observed. The problem has been more or less continuously investigated up to the present time and the majority of the evidence indicates that in vitamin B1 deficiency there is some interference with glycogen storage, hyperglycemia, and characteristic errors in carbohydrate metabolism. E...

Introduction Neurological disorders, particularly diabetic neuropathy, have been treated with vitamin B1 (thiamine) for decades; however, the bioavailability of orally administered, water-soluble thiamine salts is low compared to fat-soluble analogs. For treatment to be successful, high levels of thiamine are needed in both blood and tissues. In 1954, Fujiwara discovered a group of lipid-solubl...

The phosphorylated form of thiamine (Vitamin B1), thiamine pyrophosphate (TPP) is essential for the metabolism of amino acids and carbohydrates in all organisms. Plants and microorganisms, such as yeast, synthesize thiamine de novo whereas animals do not. The thiamine signal transduction (THI) pathway in Saccharomyces cerevisiae is well characterized. The ~10 genes required for thiamine biosynt...

The relationship of vitamin Br to carbohydrate metabolism was one of the earliest functions of a vitamin to be observed. The problem has been more or less continuously investigated up to the present time and the majority of the evidence indicates that in vitamin B1 deficiency there is some interference with glycogen storage, hyperglycemia, and characteristic errors in carbohydrate metabolism. E...

Thiamin(e), also known as vitamin B1, is now known to play a fundamental role in energy metabolism. Its discovery followed from the original early research on the 'anti-beriberi factor' found in rice polishings. After its synthesis in 1936, it led to many years of research to find its action in treating beriberi, a lethal scourge known for thousands of years, particularly in cultures dependent ...