We previously reported that purified vitexin compound 1 (VB1, a neolignan from the seed of Chinese herb Vitex negundo) exhibited antitumor activity in cancer cell lines and xenograft models. In the present study, we examined the molecular mechanisms by which activation of the FOXO3a transcription factor mediated VB1-induced apoptosis in hepatocellular carcinoma (HCC) cells. The effects of VB1 o...

Vitamin B-complex syrups were prepared using locally manufactured sucrose and liquid glucose vehicles, and stored at room temperature, 37°C and 45°C, for 6-12 months to evaluate the stability of thiamine hydrochloride. The stability testing of the syrups has been designed to determine quantitatively and qualitatively the changes which they undergo during storage. The chemical stability has been...

Herein we explore facile synthesis of 4-(3H)-Qunazolinone derivatives, achieved by the cyclocondensation of anthranilic acid, aromatic amines and triethyl orthoformate in presence of thiamine hydrochloride (Vitamin B1) as a catalyst, using grinding method. This protocol offers several advantages such as reusability of catalyst, excellent yield, shorter reaction time and economic availability.Qu...

Simple and sensitive normal and reverse flow injection methods for spectrophotometric determination of thiamine hydrochloride (THC) at the microgram level were proposed and optimized. Both methods are based on the reaction between THC and diazotized metoclopramide in alkaline medium. Beer's law was obeyed over the range of 10-300 and 2-90 μg/mL, the limits of detection were 2.118 and 0.839 μg/m...

To explore the effect of vitamin B1 on Diabetic Peripheral Neuropathy (DPN) and its mechanism for providing a theoretical basis for clinical prevention and effective treatment of diabetic neuropathy. 40 SD male rats were randomly divided into four groups (n=10/group) and they were normal control (NC) group, Diabetes Mellitus (DM) group, diabetic peripheral neuropathy (DPN) group and vitamin B1 ...

In this issue of the Journal, Coats et al (1) describe short-term thiamine pharmacokinetics in nursing women from Cambodia who received a therapeutic course of oral thiamine for 5 d. Before supplementation, the mothers and infants were biochemically thiamine deficient. Treatment normalized thiamine status in the mothers but not in the infants, although thiamine concentrations in breast milk inc...