Review on Biological Activities of 1,3,4-Thiadiazole DerivativesArvind k. Singh, Geeta Mishra, Kshitiz Jyoti

Dibromoderivatives of benzofused chalcogen-nitrogen heterocycles are important precursors in the synthesis various photovoltaic materials. 4,7-Dibromobenzo[d][1,2,3]thiadiazole is a practically unexplored compound this series. In communication, it was shown that nucleophilic substitution 4,7-dibromobenzo[d][1,2,3]thiadiazole with morpholine gave selectively 4-substituted product—4-(7-bromobenzo...

Starting from 4-chlorobenzoic acid, 10 new 5-(4-chlorophenyl)-N-substituted-N-1,3,4-thiadiazole-2-sulfonamide derivatives were synthesized in six-steps. Esterification of 4-chlorobenzoic acid with methanol and subsequent hydrazination, salt formation and cyclization afforded 5-(4-chlorophen-yl)-1,3,4-thiadiazole-2-thiol (5). Conversion of this intermediate into sulfonyl chloride 6, followed by ...

A route to methyl pyrrolo[2,3-d][1,2,3]thiadiazole-6-carboxylates as potential plant activators and inducers of systemic acquired resistance (SAR) is reported. A synthetic strategy based on cyclization of the thiadiazole ring system utilizing thionyl chloride via the Hurd-Mori protocol as key step was developed. Success of the ring closure reaction turned out to be highly dependent on the natur...

Photochemistry of 4-phenyl-1,2,3-thiadiazole (PT) and 4,5-diphenyl-1,2,3-thiadiazole (DPT) in solution was studied at room temperature using UV-vis and IR transient absorption spectroscopies (λ(ex) = 266 nm). Ultrafast techniques show a very fast rise (<0.3 ps) of thiirene and thioketene species, formed from 1,2,3-thiadiazoles in the singlet excited state. The remarkable unimolecular stability ...

The chemistry of 1,3,4-thiadiazole is one the most interesting scaffolds for synthesizing new drug molecules due to their numerous pharmacological activities. Several modifications in thiadiazole ring have been made, proving it be more potent and highly effective with a less toxic scaffold various biological There are several marketed drugs containing structure. In this review article, we tried...

Reaction of sodium salt of allyl alcohol with 2-chloro-5-phenyl- l,3,4-thiadiazole gave 2-allyloxy-5-phenyl-1,3,4-thiadiazole 2. Compounds 4a and 4b could be obtained through the reaction of nitrone 3 with 2. Reaction of compound 2 with nitrone 5 afforded the final compound 6. Antifungal activity of all compounds was less than ketoconazole

A regioregular terpolymer that combines electron-deficient diketopyrrolopyrrole and benzothiadiazole units with an electron-rich dithienopyrrole unit is presented. In solar cells, the terpolymer affords an open circuit voltage of 0.52 V and a power conversion efficiency of 3.7% with a spectral response up to 1050 nm.

Dimroth rearrangement in a thiadiazole—triazole system was first observed by Kindt—Larsen and Pedersen [1] when 5-mercapto-l-phenyl-l,2,3-triazole was formed from 5-anilino-l,2,3-thiadiazole. A similar rearrangement has been ob­ served to take place with 4-substituted 5-amino-l,2,3-thiadiazoles [2] and 4-acyl-5-arylamino-l,2,3-thiadiazoles [3]. In the present work the kinetics of the rearrangem...

In this study, a novel organic depressant maleyl 5-amino-1,3,4-thiadiazole-2-thiol (MATT) was synthesized and utilized as galena in the flotation separation of molybdenite galena. The results test indicated that MATT exhibited an excellent depression ability on but barely influenced pH range 6.0–11.0. Zeta potential suggested preferentially adsorbed surface. UV-visible spectroscopy analysis sto...