Self-assembling block copolymers (poloxamers, PEG/PLA and PEG/PLGA diblock and triblock copolymers, PEG/polycaprolactone, polyether modified poly(Acrylic Acid)) with large solubility difference between hydrophilic and hydrophobic moieties have the property of forming temperature dependent micellar aggregates and, after a further temperature increase, of gellifying due to micelle aggregation or ...

Model physically associating solutions of acrylic triblock copolymer molecules in a midblock-selective solvent displayed non-linear strain-stiffening behavior which transitioned to rapid strain softening during shear start-up experiments at reduced rates spanning almost four orders of magnitude. Softening was believed to result from the shear-induced formation of highly localized regions of def...

Thermoreversible gel of meloxicam, efficient for the treatment of joint diseases, was aimed to prepare for night application available for chronotherapy in this study. Poloxamer 407 and 188 polymers were used at 20-30% w/w as a vehicle in combination with different additives (polyvinylmethylether maleic anhydride copolymer, hydroxypropyl methylcellulose, polyethylene glycol 400, dimethyl sulfox...

The removal of Diclofenac sodium from waste waters has a high relevance since it belongs to the therapeutic group most commonly found in wastes. An aromatic-free and low-impact technology that efficiently entraps aqueous pollutants is highly desirable. We synthesised two Boc-protected tripeptides (Boc-L-Ala-Aib-L-Val-OH Boc-L-Val-Aib-L-Val-OH) studied their ability form gels with mixtures water...

Simple gel formulations may be applied to enhance the systemic and local exposure of potential compounds. The aim of this thesis is the development and characterization of controlled release formulations based on thermoreversible poloxamer gels, which are suitable for novel drug delivery applications. In particular co-solvents (DMSO, ethanol), mucoadhesive polymers (chitosan, alginate) and salt...

The dimensional stability and rheological properties of a series of comb-like copolymers of N-isopropyl acrylamide (NIPAAm) and methoxy poly(ethylene glycol) methacrylate (mPEGMA), poly(NIPAAm-co-mPEGMA), with varying poly(ethylene glycol) (PEG) graft densities and molecular weights were studied. The thermoresponsive character of the copolymer solutions was investigated by kinetic and equilibri...

This paper reports on the thermodynamics through mapping out temperature–concentration phase diagrams and molecular structure morphology of binary organogels prepared with trisamide triarylamine (TATA) in tetrachloroethane their ternary thermoreversible hybrid gels formed polyvinyl chloride (PVC). For low PVC contents, TATA organogel moiety behaves as systems, while for higher thermal behavior ...