The study of transcription remains one the centerpieces modern biology with implications in settings from development to metabolism evolution disease. Precision measurements using a host different techniques including fluorescence and sequencing readouts have raised bar for what it means quantitatively understand transcriptional regulation. In particular our understanding simplest genetic circu...

Two cycloaddition strategies are described that lead to various chroman spiroketals from assorted exocyclic enol ethers. Unlike conventional thermodynamic ketalization strategies, the stereochemical outcome for this approach is determined by a kinetic cycloaddition reaction. Thus, the stereochemical outcome reflects the olefin geometry of the starting materials along with the orientation of the...

Thermodynamic and kinetic approaches for sublimation inside elastoplastic material under tensile stress are developed for large strains. Various conceptual problems related to irreversible plastic deformation are addressed for a spherical bubble. They include definitions of the thermodynamic driving forces and activation energies, nontraditional concepts of a critical nucleus, path dependence o...