Background & Aims: Postprandial hyperglycemia results in the development of chronic complications. Therefore, its control is critical in the treatment of diabetes. One of the main therapeutic approaches for reducing postprandial hyperglycemia is to reduce the absorption of carbohydrates by enzyme inhibitors such as Acarbose which have already been clinically used as a medicine for diabetic pati...

INTRODUCTION The advancement in the telecommunications technology with multi-functional added features in mobile phone, attracts more users of all age group. It is alarming to note that, the mobile phone use has increased amongst children and they are exposed to potentially harmful radiofrequency radiation in their lifetime. AIM To investigate the long term exposure of 900 to 1800 MHz radiati...

Intravenous administration of high-dose ascorbic acid (AA) has been reported as a treatment for cancer patients. However, cancer patients with renal failure cannot receive this therapy because high-dose AA infusion can have side effects. To solve this problem, we evaluated the antitumor activity of a lipophilic stable AA derivative, 2-O-α-d-glucopyranosyl-6-O-(2-pentylheptanoyl)-l-ascorbic acid...

A CD4(+) T cell clone (HC/2G-1) was established by stimulating peripheral blood T cells from a patient with renal cell carcinoma (RCC) with dendritic cells preincubated with the autologous apoptotic renal tumor line in the presence of IFN-alpha. It recognizes the autologous RCC and most allogeneic RCC lines by IFN-gamma release (10 of 11 lines) and lysis (9 of 10 lines), but does not recognize ...

Gene manipulation using the Cre/loxP-recombinase system has been successfully employed in zebrafish to study gene functions and lineage relationships. Recently, gene trapping approaches have been applied to produce large collections of transgenic fish expressing conditional alleles in various tissues. However, the limited number of available cell- and tissue-specific Cre/CreERT2-driver lines st...

The advent of 3G wireless technologies is obviously relegating the 2G network, gradually pushing them into oblivion. The shortcomings of 2G are the platform that brought about the development of 3G but this does not justify it to be scrapped. This paper will analyze these shortcomings and try to bring out the potentials of the 2G system which can still be garnered. This analysis will be based o...

The global system for mobile communications, (GSM) is the most popular standard that implements second generation (2G) cellular systems. 2G systems combined with general packet radio services (GPRS) (3GPP TS 03.6, 2002) are often described as 2.5G, that is, a technology between the 2G and third generation (3G) of mobile systems. GPRS is a service that provides packet radio access for GSM users....

Stoichiometric evaluation of the radical scavenging activity of O-substituted derivatives at the C-2 position of ascorbic acid (AA) was conducted. Their reaction with a stable radical, 1,1-diphenyl-2-picrylhydrazyl (DPPH), under an acidic condition was assessed by the colorimetric method. 2-O-alpha-D-Glucopyranosyl-L-ascorbic acid (AA-2G) and a series of 6-O-acyl-2-O-alpha-D-glucopyranosyl-L-as...

Controversy exists over whether the predominant cell death of hepatocytes is due to apoptosis or necrosis after ischemia/reperfusion injury. In this study we investigated the predominant cell death of hepatocytes after cold ischemia/reperfusion injury using the Annexin V-based assay, and evaluated the anti-apoptotic effect of ascorbic acid 2-glucoside (AA-2G) added to the University of Wisconsi...