AIMS Our aim was to clarify the location and structure of the outlet septum relative to the free-standing subpulmonary infundibulum in the setting of tetralogy of Fallot and to examine its relationship to the other components of the subpulmonary outflow tract, determining their potential influence on clinical outcome. METHODS AND RESULTS We studied prospectively 41 patients with tetralogy of ...

The number of adults with repaired tetralogy of Fallot is increasing. Aortic root dilatation has been observed on longitudinal follow-up of patients with tetralogy of Fallot. Histological studies of aortas in patients with tetralogy of Fallot have reported striking similarities to the aortas of patients with Marfan syndrome. Despite the concern that patients with tetralogy of Fallot may harbor ...

Four patients with primitive ventricle and normally related great vessels with stenotic subpulmonary outlet chamber (Holmes' heart with pulmonary stenosis) are reported. The history, physical examination, and chest x-ray film are not helpful in distinguishing Holmes' heart with pulmonary stenosis from tetralogy of Fallot. Electrocardiogram often provides the first clue to the presence of Holmes...

Chromosome 22q11 fluorescence in situ hybridisation (FISH) studies were performed on 33 consecutive individuals attending a paediatric cardiology clinic with tetralogy of Fallot. Seven children had 22q11 microdeletions but only four had other clinical features associated with the newly recognised chromosome 22 deletion syndrome (CATCH 22). Chromosome 22q11 FISH studies should therefore be perfo...

Progressive aortic root dilatation is a common feature after surgical repair of tetralogy of Fallot. This report describes a successful valve-sparing replacement of the aortic root in a patient with significant dilated aortic root and aortic regurgitation after repair of tetralogy of Fallot.

were confirmed in both isolated pulmonary stenosis and tetralogy of Fallot but were more marked in pulmonic stenosis. Intimal fibrosis in the pulmonary vessels on the other hand gave the impression of being greater in the cases of tetralogy of Fallot than in pulmonic stenosis even within the same age group, but this difference is not statistically significant. Intimal fibrosis was even more pro...

Four patients with tetralogy of Fallot syndrome, whose physical and x-ray findings were distinctly unusual, are presented in this report. All these patients were demonstrated to have functional or anatomic atresia of one of the main pulmonary arteries, in addition to the characteristic features of the tetralogy of Fallot. Diagnostic criteria, including angiocardiograms, are presented, and the t...

Four patients with tetralogy of Fallot syndrome, whose physical and x-ray findings were distinctly unusual, are presented in this report. All these patients were demonstrated to have functional or anatomic atresia of one of the main pulmonary arteries, in addition to the characteristic features of the tetralogy of Fallot. Diagnostic criteria, including angiocardiograms, are presented, and the t...

Dr. J. A. DAVIS: The patient (Case No. 298928, P.M. No. 11116) we are about to discuss was a male infant born on 30 December 1964. He was the child of the third pregnancy of a 25-year-old woman with a proved Fallot's tetralogy. The first pregnancy had ended in an abortion at 3 months; the second yielded a live infant who weighed only 1,420 g. at 37 weeks' gestation and died at the age of 30 hou...

Tetralogy of Fallot is the most common form of cyanotic congenital heart disease, and one of the first to be successfully repaired by congenital heart surgeons. Since the first procedures in the 1950s, advances in the diagnosis, perioperative and surgical treatment, and postoperative care have been such that almost all those born with tetralogy of Fallot can now expect to survive to adulthood. ...