Maca, a plant native to the Peruvian highlands, contains (1R,3S)-1-methyl-1,2,3,4-tetrahydro-beta-carboline-3-carboxylic acid (MTCA). The family of the tetrahydro-beta-carbolines has been associated with both biologically helpful and harmful compounds. We present evidence that MTCA is a natural constituent of Maca, and on consumption no toxicity is found. This suggests that, when consumed as mu...

A multi-bond forming, three-step tandem process involving a palladium(II)-catalysed Overman rearrangement and a ring closing metathesis reaction has been utilised for the efficient synthesis of a 2,3,6,7-tetrahydro-3-amidoazepine. Substrate directed epoxidation or dihydroxylation of this synthetic intermediate has allowed the diastereoselective synthesis of hydroxylated 3-aminoazepanes includin...

Tetrahydro-1H-benzo[b]azonin-2,7-dione (2a) has been used as a precursor in the synthesis of dibenzo[b,f ][1,5]diazacyclododecene and dibenzo[b,g][1,6]diazacyclododecene ring systems 4 and 5, respectively, via periodate oxidation of the appropriate indolo-benzo[b]azonines 3 and 7. The synthesis of hexahydro-benzo[b][1,4]diazecin-2,7-dione (10) has been achieved by the Schmidt reaction of 2a. Th...

In 1-cyclohexyl-6,6,8a-trimethyl-3a,6,7,8a-tetrahydro-1H-1-benzofuro[2,3-b]pyrrole-2,4(3H,5H)-dione, C19H27NO3, (I), and the isomorphous compounds 6,6,8a-trimethyl-1-phenyl-3a,6,7,8a-tetrahydro-1H-1-benzofuro[2,3-b]pyrrole-2,4(3H,5H)-dione, C19H21NO3, (II), and 6,6,8a-trimethyl-1-(3-pyridyl)-3a,6,7,8a-tetrahydro-1H-1-benzofuro[2,3-b]pyrrole-2,4(3H,5H)-dione, C18H20N2O3, (III), the tetrahydroben...

Many alkaloids containing a tetrahydro-β-carboline skeleton have well-known therapeutic effects, leading to increased interest in the synthesis of these natural products. Enantiomers of N-Boc-protected 1-hydroxymethyl-1,2,3,4-tetrahydro-β-carboline [(±)-7], 1-hydroxymethyl-6-methoxy-1,2,3,4-tetrahydro-β-carboline [(±)-8], and 1-hydroxymethyl-6-fluoro-1,2,3,4-tetrahydro-β-carboline [(±)-9] were ...

Synthesis and anti-microbial screening thiazoloquinazoline derivatives Abstract A series of some new 6,7,8,9-Tetrahydro-5H-5(2'-hydroxyphenyl)-2-(4'-fluorobenzylidine)-3-(4nitrophenyl amino) thiazolo quinazoline (4a-4d) and 6,7,8,9-Tetrahydro-5H-5-(2'-hydroxy phenyl)2-(4'-substituted benzylidine)-3-(4-nitrophenyl amino) thiazolo quinazoline (5a-5d) derivatives were synthesized. The in vitro ant...

(E)-5-(Methoxyimino)-1,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one was prepared by a condensation reaction from 3,4-dihydro-1H-benzo[b]azepin-2,5-dione and O-methylhydroxylamine. The configuration at the C=N double bond determined X-ray crystallography.

Dibenz[a,h]anthracene (DB[a,h]A) and its microsomal metabolites, trans-3,4-dihydro-3,4-dihydroxydibenz[a,h]anthracene (DBA-3,4-diol), trans,trans-3,4:8,9-tetrahydro-3,4:8,9-tetrahydroxydibenz[a,h]anth racene, trans,trans-3,4:10,11-tetrahydro-3,4:10,11-tetrahydroxydibenz[a,h] - anthracene (DBA-3,4,10,11-bis-diol) and trans,trans-3,4:12,13-tetrahydro-3,4:12,13- tetrahydroxydibenz[a,h]anthracene w...

The effects of 14 -carbolines on human platelet aggregability were comparatively studied, and the effects on lipid membranes were determined. Several -carbolines inhibited platelet aggregation induced by collagen, epinephrine, adenosine 5’-diphosphate, platelet-activating factor and thrombin. This activity was structure-dependent. Of all the compounds examined, 1-methyl-1,2,3,4tetrahydro-carbol...

F r a n z D a l l a c k e r * , G e r m a n u s R e i c h r a t h u n d G e r a r d S c h n a c k e r s Institut für Organische Chemie der Technischen Hochschule Aachen, Prof.-Pirlet-Straße 1, D-5100 Aachen Z. Naturforsch. 34b, 624-632 (1979); eingegangen am 13. November 1978 5,6-Dimethyl-l,3-benzodioxole-4,7-quinone, 6,7-Dimethyl-l,4-benzodioxan-5,8-quinone, 7,8 -Dimethyl 3,4 -dihy dro 2 H -1,...