Testicular torsion results with the damage of the testis and it is a surgical emergency. Pyrrolidine dithiocarbamate (PDTC) is a low-molecular-weight antioxidant and potent inhibitor of nuclear factor kappa B (NF-κB) activation. In this study, we aimed to investigate the effects of PDTC to testicular torsion-detorsion (T/D) injury. Forty adult male Sprague-Dawley rats were separated into four g...

Peroxisomes are organelles responsible for multiple metabolic pathways including, the biosynthesis of plasmalogens, a class of phospholipids, and the beta-oxidation of very-long-chain fatty acids (VLCFA). Lack of peroxisomes or dysfunction in any of their normal functions is the cellular basis for human peroxisomal disorders. Here we used mouse models to understand and define the biochemical an...

Background: Among new therapies emerging in the medical field, use of platelet-rich plasma (PRP) human reproduction has not yet been explored. Platelet-rich a potential effect on tissue repair through proliferation and differentiation progenitor cells. The aim this study was to evaluate PRP testis structure function rabbit model. Material methods: A total 30 male rabbits were recruited study. T...

Objectives: This study aimed to evaluate the effect of anthocyanin on oxidative stress, sperm, and testis structure in diabetic rats induced by streptozotocin (STZ). Materials Methods: In this experimental research, diabetes was a single intraperitoneal injection STZ (50 mg/ kg). A total 64 were assigned into four groups as follows: control group, group daily administrated with at dose 100 mg/k...

splenogonadal fusion is a rare congenital malformation whereby the splenic tissue is found attached or surrounded by the testis, and presents in both continuous and discontinuous forms. splenogonadal fusion may be misinterpreted as a primary malignant testicular or an adenomatoid tumor. knowledge about the existence of such an entity is essential in order to preserve the testis during surgical ...

Cadmium can cause oxidative damage in organisms through overproduction of free radicals and suppression the antioxidant defense system. Resveratrol is known as a nutraceutical with properties accepted to have protective effects toxicity heavy metals. In this study, we investigated if resveratrol could overwhelm toxic effect sub-acute cadmium exposure. Animals were divided following groups: 1) C...

quantum dots are new types of fluorescent materials for biological labeling. as a result, qds toxicity study is an essential requirement for future clinical applications. therefore, the cytotoxic cdse:zns quantum dots effects on some organs in mice are presented in this study. in this work, 10, 20 and 40 mg/kg doses of cdse:zns quantum dots were injected to 32 adult male mice. structural and op...

objective(s):cyclophosphamide (cp) toxicity on testis was hampered by squid ink polysaccharide (sip) via restoration of antioxidant ability in our previous investigations. this study investigated roles of nrf2/are signal pathway in testis of treated mice. materials and methods: male kunming mice were employed to undergo treatment with sip and/or cp. protein levels of nrf2, keap-1, histone deace...

Background: Chronic diabetes mellitus is accompanied with enhanced oxidative stress and reduce the activity of antioxidant defense system. Due to significant role of enhanced oxidative stress in development of testes damage in diabetices, this study was conducted to evaluate the effect of royal jelly on oxidative stress marker in testis tissue of diabetic rats. Materials and Methods: In this ex...