Pancreatic ductal adenocarcinoma (PDAC) is associated with pronounced fibrosis, which can either promote tumor progression by physically preventing chemotherapy drugs and immune cells from targeting tumor cells, or inhibit tumor progression by decreasing tumor cell invasion. Elucidation of the relationship between tumor genotype and fibrotic phenotype could identify the PDACs that would benefit...

Ripples present in free standing graphene have an important influence on the mechanical behavior of this two-dimensional material. In this study, we show through nanoindentation simulations, how out-of-plane displacements can be modified by strain, resulting in softening of the membrane under compression and stiffening under tension. Irradiation also induces changes in the mechanical properties...

The stiffness of articular cartilage is a nonlinear function of the strain amplitude and strain rate as well as the loading history, as a consequence of the flow of interstitial water and the stiffening of the collagen fibril network. This paper presents a full investigation of the interplay between the fluid kinetics and fibril stiffening of unconfined cartilage disks by analyzing over 200 cas...