It is well known that microRNAs (miRNAs) play important roles in cancer development by targeting oncogenes or tumor-suppressor genes. However, little is known regarding the mechanisms of miR-30c action in endometrial cancer. In this study, we aimed to determine whether miR-30c targets metastasis-associated gene-1 (MTA1) and acts as a tumor suppres...

miR-30c has been reported to act as a tumor suppressor and negatively regulate cancer metastasis by directly targeting metastasis associated genes; however, miR-30c has also been shown to promote the invasion of metastatic breast cancer cells, suggesting that miR-30c might be involved in cancer cell metastasis in different ways via targeting different genes. In this study, we demonstrated that ...

Systemic sclerosis (SSc) is characterized by peripheral circulatory disturbance and fibrosis in skin visceral organs. We recently demonstrated that ?2-antiplasmin (?2AP) elevated SSc dermal fibroblasts model mice, associated with progression vascular dysfunction. In the present study, we predicted ?2AP could be a target of microRNA-30c (miR-30c) using TargetScan online database, investigated ef...

When lettuce seeds are imbibed and subjected to high temperature for periods of 72 h or more, dormancy known as thermodormaney is induced. Priming of three cultivars of lettuce ( Lactuca sativa L.) seeds in 1% (w/v) K3P O4 for 20 h in the dark reduced thermodormaney. Addition of 100 mg 6-benzyladenine (BA)/liter to the priming solution increased germination in petri dishes at 35C in ‘Green Lake...

Aneurysmal subarachnoid hemorrhage is a severe neurological disease that characterized by acute onset, multiple complications and poor prognosis. The aim of this study was to analyze the relationship between expression level micro ribonucleic acid-30c in plasma prognosis patients with aneurysmal hemorrhage. A total 181 were prospectively selected as subjects. Modified Rankin scale used evaluate...

MicroRNAs (miRNAs) are small noncoding RNAs that function as master regulators of posttranscriptional gene expression with each miRNA negatively regulating hundreds of genes. Lysophosphatidic acid (LPA) is a mitogenic lipid present within the ovarian tumor microenvironment and induces LPA receptor activation and intracellular signaling cascades like ERK/MAPK, leading to enhanced cellular prolif...

Microsomal triglyceride transfer protein (MTTP) is an essential chaperone that assists in the assembly of apolipoprotein B-containing lipoproteins to transport lipids. We have shown that microRNA (miR)-30c regulates MTTP expression but other members of the same family do not. Further, we showed that interactions between miR-30c seed sequence and the 3΄-untranslated region (UTR) of the MTTP mRNA...

The transcription factor CCAAT enhancer binding protein α (C/EBPα) is a master regulator in granulopoiesis and is frequently disrupted in acute myeloid leukemia (AML). We have previously shown that C/EBPα exerts its effects by regulating microRNAs (miRs) such as miR-223 and miR-34a. Here, we confirm miR-30c as a novel important target of C/EBPα during granulopoiesis. Thus, wild-type C/EBPα-p42 ...

We study the rheology of semi-dilute solutions of the sodium salt of calf-thymus DNA in the linear and nonlinear regimes. The frequency response data can be fitted very well to the hybrid model with two dominant relaxation times τ0 and τ1. The ratio (τ0=τ1) 5 is seen to be fairly constant on changing the temperature from 20 to 30C. The shear rate dependence of viscosity can be fitted to the Car...