نتایج جستجو برای: tem cells

تعداد نتایج: 1418823  

Journal: :Journal of immunology 2012
Veronica Azcutia Michael Stefanidakis Naotake Tsuboi Tanya Mayadas Kevin J Croce Daiju Fukuda Masanori Aikawa Gail Newton Francis W Luscinskas

At sites of inflammation, endothelial adhesion molecules bind leukocytes and transmit signals required for transendothelial migration (TEM). We previously reported that adhesive interactions between endothelial cell CD47 and leukocyte signal regulatory protein γ (SIRPγ) regulate human T cell TEM. The role of endothelial CD47 in T cell TEM in vivo, however, has not been explored. In this study, ...

Journal: :Biology of the cell 2008
Philippe Roingeard

Viruses are very small and most of them can be seen only by TEM (transmission electron microscopy). TEM has therefore made a major contribution to virology, including the discovery of many viruses, the diagnosis of various viral infections and fundamental investigations of virus-host cell interactions. However, TEM has gradually been replaced by more sensitive methods, such as the PCR. In resea...

2015
Yibing Wang Xin Chen Hongliang Cao Chao Deng Xiaodan Cao Ping Wang

Studying cell microstructures and their behaviors under living conditions has been a challenging subject in microbiology. In this work, in situ liquid chamber TEM was used to study structures of Escherichia coli cells in aqueous solutions at a nanometer-scale resolution. Most of the cells remained intact under electron beam irradiation, and nanoscale structures were observed during the TEM imag...

Journal: :Journal of immunology 2016
Jason M Schenkel Kathryn A Fraser Kerry A Casey Lalit K Beura Kristen E Pauken Vaiva Vezys David Masopust

IL-15 regulates central and effector memory CD8 T cell (TCM and TEM, respectively) homeostatic proliferation, maintenance, and longevity. Consequently, IL-15 availability hypothetically defines the carrying capacity for total memory CD8 T cells within the host. In conflict with this hypothesis, previous observations demonstrated that boosting generates preternaturally abundant TEM that increase...

Journal: :Journal of immunology 2003
Karkada Mohan Devanand Pinto Thomas B Issekutz

During inflammation, T lymphocytes migrate out of the blood across the vascular endothelium in a multistep process. The receptors mediating T cell adhesion to endothelium are well characterized; however, the molecules involved in T cell transendothelial migration (TEM) subsequent to lymphocyte adhesion to the endothelium are less clear. To identify receptors mediating TEM, mAbs were produced ag...

Background: Nicotine as a toxic agent in cigarette has detrimental effects on reproduction. The aim of this study was to evaluate effects of of nicotine on germ and somatic cells in adult mouse testis. Materials and Methods: Male mice were divided into four groups. Group A or controls, groups of B, C and D were treated with nicotine intraperitoneally in doses of 0.1, 0.2 and 0.4 mg/100 g body w...

2015
Suranjana Mukherjee Joanna Kim Olivia L. Mooren Stefanie T. Shahan Megan Cohan John A. Cooper

Natural Killer (NK) cells perform many functions that depend on actin assembly, including adhesion, chemotaxis, lytic synapse assembly and cytolysis. HS1, the hematopoietic homolog of cortactin, binds to Arp2/3 complex and promotes actin assembly by helping to form and stabilize actin filament branches. We investigated the role of HS1 in transendothelial migration (TEM) by NK cells. Depletion o...

Journal: :Ultrastructural pathology 2005
Yong-Xin Ru Hui-Jun Wang Bing-Xin Yang Jin-Hua Liu Zhan-Qi Li Cheng-Wen Li Jian-Xiang Wang Ying-Chang Mi

The objective of this study was to investigate the ultrastructural characteristics of hybrid acute leukemia (HAL). Fifteen cases of HAL were studied by transmission electron microscopy (TEM), focusing on organelles and myeloperoxidase (MPO) reaction of leukemic cells. By TEM, 5 out 15 cases of HAL were consistent with immunophenotyping (3 cases of biphenotypic type, and 2 cases of biclonal type...

Journal: :Journal of cell science 2004
Yusuke Oshima Koji Sato Fumi Tashiro Jun-ichi Miyazaki Koji Nishida Yuji Hiraki Yasuo Tano Chisa Shukunami

Tenomodulin (TeM) is a type II transmembrane glycoprotein that contains a C-terminal domain with homology to the mature, secreted form of chondromodulin-I (ChM-I), a cartilage-derived angiogenesis inhibitor. TeM transcripts have been found in hypovascular tissues such as tendons and ligaments but the biological activity of TeM has not yet been fully explored. Using an adenovirus expression syst...

2016
Pravin Kesarwani Paramita Chakraborty Radhika Gudi Shilpak Chatterjee Gina Scurti Kyle Toth Patt Simms Mahvash Husain Kent Armeson Shahid Husain Elizabeth Garrett-Mayer Chethamarakshan Vasu Michael I. Nishimura Shikhar Mehrotra

Advancements in adoptive cell transfer therapy (ACT) has led to the use of T cells engineered with tumor specific T cell receptors, which after rapid expansion can be obtained in sufficient numbers for treating patients. However, due to massive proliferation these cells are close to replicative senescence, exhibit exhausted phenotype, and also display increased susceptibility to activation indu...

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