نتایج جستجو برای: tcr

تعداد نتایج: 12834  

2015
Eliana Ruggiero Jan P. Nicolay Raffaele Fronza Anne Arens Anna Paruzynski Ali Nowrouzi Gökçe Ürenden Christina Lulay Sven Schneider Sergij Goerdt Hanno Glimm Peter H. Krammer Manfred Schmidt Christof von Kalle

Unbiased dissection of T-cell receptor (TCR) repertoire diversity at the nucleotide level could provide important insights into human immunity. Here we show that TCR ligation-anchored-magnetically captured PCR (TCR-LA-MC PCR) identifies TCR α- and β-chain diversity without sequence-associated or quantitative restrictions in healthy and diseased conditions. TCR-LA-MC PCR identifies convergent re...

Journal: :Blood 1989
J J van Dongen I L Wolvers-Tettero F Wassenaar J Borst P van den Elsen

We have analyzed T-cell receptor delta (TcR-delta) gene rearrangement and transcription in appropriately phenotyped mononuclear cells derived from 12 patients with T-cell acute lymphoblastic leukemia (T-ALL). The T-ALL cells were also analyzed for rearrangement and transcription of the T-cell receptor(TcR)-beta and gamma genes as well as for the presence of TcR-alpha gene transcripts. Four T-AL...

Journal: :Blood 1991
D Campana J J van Dongen A Mehta E Coustan-Smith I L Wolvers-Tettero K Ganeshaguru G Janossy

In this study five monoclonal antibodies (MoAbs) to T-cell receptor (TCR) proteins (WT31, alpha F1, beta F1, TCR delta-1 and delta TCS-1) were used to identify discrete maturative stages in 40 cases of T-cell acute lymphoblastic leukemia (T-ALL). These MoAbs reacted exclusively with CD3+ T cells and did not label B-lineage and myeloid cells. In 17 of the 40 T-ALL cases studied the leukemic blas...

Journal: :Journal of Immunology 2023

Abstract Noncovalent bonds typically mediate interactions between a T cell receptor (TCR) and peptide-major histocompatibility complex (pMHC) ligand. In this study, we describe novel mechanism involving covalent TCR-pMHC interaction through cysteine-cysteine disulfide bond. By introducing cysteine resodues into the TCR CDR3 peptide of known combination, show that bond formation does not require...

ژورنال: :مهندسی برق مدرس 0
rahmatllah hooshmand university of isfahan

کوره های قوس الکتریکی، بارهایی غیرخطی و متغیر با زمان هستند که باعث افت کیفیت توان در سیستمهای قدرت شده و پدیده های مرتبط با کیفیت توان را در این سیستمها باعث می ‏شوند. در صنایع فولادسازی اغلب دو کوره قوس الکتریکی با یکدیگر موازی شده و روی یک شین شبکه قرار می ‏گیرند. در این شرایط کیفیت توان به مراتب بیشتر دچار اختلال می شود. در این مقاله به منظور بررسی و تحلیل آثار زیان بار عملکرد موازی کوره ها...

2015
Kornelis S. M. van der Geest Wayel H. Abdulahad Gerda Horst Pedro G. Lorencetti Johan Bijzet Suzanne Arends Marieke van der Heiden Anne-Marie Buisman Bart-Jan Kroesen Elisabeth Brouwer Annemieke M. H. Boots

Measuring changes of the T cell receptor (TCR) repertoire is important to many fields of medicine. Flow cytometry is a popular technique to study the TCR repertoire, as it quickly provides insight into the TCR-Vβ usage among well-defined populations of T cells. However, the interpretation of the flow cytometric data remains difficult, and subtle TCR repertoire changes may go undetected. Here, w...

Journal: :The Journal of Experimental Medicine 1996
A R Ramiro C Trigueros C Márquez J L San Millán M L Toribio

In murine T cell development, early thymocytes that productively rearrange the T cell receptor (TCR) beta locus are selected to continue maturation, before TCR alpha expression, by means of a pre-TCR alpha- (pT alpha-) TCR beta heterodimer (pre-TCR). The aim of this study was to identify equivalent stages in human thymocyte development. We show here that variable-diversity-joining region TCR be...

2005
Ching-Yu Huang Barry P. Sleckman Osami Kanagawa

To become mature T cells, developing thymocytes must first assemble a T cell receptor (TCR) chain gene encoding a TCR chain that forms a pre-TCR. These cells then need to generate a TCR chain gene encoding a TCR chain, which, when paired with the TCR chain, forms a selectable TCR. Newly generated VJ rearrangements that do not encode TCR chains capable of forming selectable TCRs can be excised f...

Journal: :The Journal of Experimental Medicine 1995
K P Kearse Y Takahama J A Punt S O Sharrow A Singer

Differentiation of immature CD4+ CD8+ thymocytes into mature CD4+ or CD8+ T cells occurs within the thymus and is dependent upon expression of antigen receptor complexes (T cell receptor [TCR]) containing clonotypic alpha/beta proteins. We have recently found that CD4+ CD8+ thymocytes express low levels of surface TCR because of limitations placed on TCR assembly by the instability of nascent T...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2010
Marleen M van Loenen Renate de Boer Avital L Amir Renate S Hagedoorn Gerdien L Volbeda Roelof Willemze Johannes J van Rood J H Frederik Falkenburg Mirjam H M Heemskerk

Adoptive transfer of T cell receptor (TCR)-transduced T cells may be an attractive strategy to target both hematological malignancies and solid tumors. By introducing a TCR, large numbers of T cells with defined antigen (Ag) specificity can be obtained. However, by introduction of a TCR, mixed TCR dimers can be formed. Besides the decrease in TCR expression of the introduced and endogenous TCR,...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید