BACKGROUND Previous experiments have shown that tumour-associated antigens can be exploited for a successful anti-tumour immunisation. Previous reports demonstrated that oncoprotein MDM2 (HDM2) contains two highly conserved MHC class I binding motifs, MDM2100 and MDM2441, and that dendritic cells (DC) presenting MDM2100 stimulate an effective CTL reaction against melanoma cells. MATERIALS AND...

CRAC (Calcium Release-Activated Calcium) channels represent the primary pathway for so-called "store-operated calcium entry" - the cellular entry of calcium induced by depletion of intracellular calcium stores. These channels play a key role in diverse cellular activities, most noticeably in the differentiation and activation of Tcells, and in the response of mast cells to inflammatory signals....

The marine environment has proven to be a very rich source of extremely potent compounds that have demonstrated significant activities in antitumor, anti-parasitic, anti-microbial, anti-coagulants’, antiviral, cytotoxic compounds, anti-inflammatory, proteins. Aplidine is a promosing anti-tumor agent that is derived from the Mediterranean tunicate Aplidum albicans. We have found that aplidine at...

Localized cutaneous leishmaniasis caused by Leishmania braziliensis can either respond well or poorly to the treatment heal spontaneously; It seems be dependent on parasite and/or host factors, but mechanisms are not fully understood. We evaluated in situ immune response eighty-two active lesions from fifty-eight patients prior classified as early spontaneous regression (SRL-n = 14); responders...

Recent clinical trials targeting the OX40-OX40L axis in atopic dermatitis/AD (AMG451, KHK4083, and KY1005) suggest potential for long-term disease modification. While inflammatory models that upregulate effector T cell survival inhibit Foxp3+ Tregs, mechanism of action remains unelucidated. We assessed OX40 OX40L expressing cells skin blood AD patients, identifying how they regulate effectors T...

Dermatomyositis (DM) is a chronic, systemic autoimmune disease affecting the skin, muscle, and lungs. Lenabasum, non-psychoactive cannabinoid type 2 receptor (CB2R) agonist, currently being investigated as non-immunosuppressive treatment option for DM. The activation of CB2R has been shown to reduce several key pro-inflammatory cytokines implicated in Our lab previously demonstrated via immunoh...