PURPOSE The aim was to investigate the effect of low dose doxycycline (20 mg) therapy in patients with chronic meibomian gland dysfunction that were refractory to conventional therapy. METHODS The randomized prospective study enrolled 150 patients (300 eyes) who have chronic meibomian gland dysfunction and who didn't respond to lid hygiene and topical therapy for more than 2 months. All topic...

PURPOSE To investigate the effect of omega-3 polyunsaturated fatty acid supplement on qualitative and quantitative subjective (ocular surface disease index [OSDI]) and objective (Schirmer's test, tear break up time [TBUT], and tear osmolarity) dry eye indices after cataract surgery. METHODS In this randomized clinical study, 61 eyes of 48 patients complaining of new onset dry eye symptoms aft...

OBJECTIVES To investigate tear ferning (TF) test repeatability between sessions by observing changes in the tear fern pattern during the day. METHODS Twenty-three healthy young adults (15 men and 8 women), ranging in age from 20 to 32 years (mean ± SD: 22.9 ± 3.3 years) without signs or symptoms of dry eye disease, ocular disease, or contact lens wear were enrolled in the study. Schirmer I, t...

PURPOSE Colostrum has been proposed to treat severe dryness and problematic eye lesions showing a beneficial effect. The aim of the study was to investigate the effect of 2-fucosyl-lactose, a natural sugar present in the human colostrum, in an experimental dry eye. METHODS Dry eye was induced in adult male New Zealand albino rabbits by topical administration of 1% atropine. Tear volume (Schir...

PURPOSE The aim of this study was to assess signs and symptoms of ocular surface disease (OSD) and the cytomorphological changes of ocular surface in glaucoma patients using preserved antiglaucoma drops. METHODS In this cross-sectional study, 109 participants (79 patients with topical medication and 30 untreated controls) completed the Ocular Surface Diseases Index (OSDI) questionnaire and un...

OBJECTIVES To investigate the effect of systemic infliximab therapy on tear function tests and the ocular surface in patients with Sjögren's syndrome secondary to various autoimmune diseases. MA­TE­RI­ALS AND MET­HODS This prospective study included 22 eyes of 22 patients with Sjögren's syndrome who began treatment with systemic infliximab. Tear film break-up time (TBUT), anesthetized Schirme...

PURPOSE The aim of this study was to explore the relationship between chronic cigarette smoking and meibomian gland dysfunction (MGD). METHODS This study enrolled 322 smokers with MGD and 2067 non-smokers with MGD. All enrolled subjects were tested in the following sequence: Ocular Surface Disease Index (OSDI), tear film breakup time (TBUT), corneal fluorescein staining (CFS), Schirmer I test...

OBJECTIVE To evaluate the efficacy and tolerability of Optive, a new dry eye product containing sodium carboxymethylcellulose (0.5%) and glycerol (0.9%), in patients with keratoconjunctivitis sicca (KCS). METHODS This was a non-interventional and observational study including patients with dry eye who required a change of medication or were naïve to dry eye treatment (N = 5,277). Disease seve...

IMPORTANCE Botulinum toxin injection for lateral canthal rhytids has been reported to result in dry eye, but its effect on tear film stability and tear production has not been studied thoroughly. OBJECTIVE To investigate the effect of botulinum toxin type A on tear film stability and tear production after treatment of lateral canthal rhytids. DESIGN, SETTING, AND PARTICIPANTS We performed a...

Dry eye is often an under diagnosed condition of the that can cause discomfort, burning sensation and blurred vision. These symptoms are related to alterations in layers tear film, insufficient production or excessive evaporation film. The primary aim this study diagnose find out incidence dry patients presenting with ocular irritation. A total number 225 both sexes aged between 20 80 years com...