Paclitaxel (Taxol®) is a potent anticancer agent, but the widespread pharmaceutical use of paclitaxel hampered by its limited availability due to low accumulation levels in native yew (Taxus spp.) plants. Currently, hairy root culture an emerging biotechnological tool that presents several advantages such as reduced costs and higher specialized metabolite production, therefore, application prod...

Bu çalışmada, Zonguldak Gökgöl Mağarası yakınlarında Doğu kayını (Fagus orientalis Lipsky), Anadolu kestanesi (Castanea sativa Mill.) ve Adi gürgen (Carpinus betulus L.) türlerinden oluşan karışık meşcerede münferit halde bulunan 4 adet yaşlı Taxus baccata L. bireyinin anıtsal özellikleri incelenmiştir. Tahmini yaşları 915 ila 1180 arasında değişen bu ağaçların Şimdiki Anıtsal Değerleri (ŞAD) 7...

it has been reported that several conifers possess cytotoxic activities on some human tumor cell lines. taxol as a natural cytotoxic compound has been extracted from this family. in a program to screen the cytotoxic effects of natural resources, male and female branchlets, fruit or bark of two different species of iranian conifers were collected, identified and the cytotoxic effects of their hy...

Abstract Background In humans, various diseases are associated with the accumulation of free radicals. The antioxidants can scavenge radicals and reduce their impact; thus, search for effective natural plant origin is indispensable. present study aims to determine, first time, flavonoid compounds profile investigate radical scavenging antioxidant properties methanolic extract Taxus baccata L. f...