A series of 26 breast cancer patients were mobilized with G-CSF after a course of TAF (taxotere-adriamycin-5-fluorouracil). The median number of CD34+ cells collected in the first large-volume leukapheresis was 5.4x106/kg. The scheduled positive/negative CD34+ selection could be performed in 25 cases. This combination of three of the most active drugs for breast cancer allows optimal cellular y...

Herein we report the fabrication of engineered poly(lactic acid-co-glycolic acid) nanoparticles via the PRINT (particle replication in nonwetting templates) process with high and efficient loadings of docetaxel, up to 40% (w/w) with encapsulation efficiencies >90%. The PRINT process enables independent control of particle properties leading to a higher degree of tailorability than traditional m...

Docetaxel (Taxotere) and vinorelbine (Navelbine) are two of a number of new third-generation chemotherapeutic agents that have become available in recent years. A series of single-agent and combination therapy studies are underway to determine the efficacy of these agents in the treatment of patients with non-small-cell lung cancer. Although docetaxel and vinorelbine are considered tubulin-bind...

BACKGROUND The INTEREST (IRESSA NSCLC Trial Evaluating Response and Survival against Taxotere) trial compared gefitinib with docetaxel (Taxotere) in pretreated advanced non-small-cell lung cancer (NSCLC). Noninferiority for overall survival was concluded. Gefitinib had a better toxicity profile and greater improvements in quality of life (QoL). We undertook a cost-consequence analysis to estima...