INTRODUCTION We aimed to quantify and identify associated factors of linkage to HIV care following home-based HIV counselling and testing (HBHCT) in the ongoing ANRS 12249 treatment-as-prevention (TasP) cluster-randomized trial in rural KwaZulu-Natal, South Africa. METHODS Individuals ≥16 years were offered HBHCT; those who were identified HIV positive were referred to cluster-based TasP clin...

It remains unclear what proportions of HIV-infected and uninfected people should receive effective antiretroviral therapy (ART) to control local HIV epidemics. We developed a flexible model to evaluate the impact of treatment as prevention (TasP) and pre-exposure prophylaxis (PrEP) on HIV incidence in local communities. We evaluated this tool for determining what TasP and PrEP targets are neede...

OBJECTIVE We compared the impact and costs of HIV prevention strategies focusing on youth (15-24 year-old persons) versus on adults (15+ year-old persons), in a high-HIV burden context of a large generalized epidemic. DESIGN Compartmental age-structured mathematical model of HIV transmission in Nyanza, Kenya. INTERVENTIONS The interventions focused on youth were high coverage HIV testing (8...

Preexposure prophylaxis (PrEP) and treatment as prevention (TasP) involve the use of antiretroviral (ARV) drugs by human immunodeficiency virus (HIV)-negative and -positive individuals to reduce HIV acquisition and transmission, respectively. Clinical science has delivered a consistently high effect size for TasP and a range from 0%-73% reduction in incidence across placebo-controlled PrEP tria...

The concept of template-assembled synthetic proteins (TASP) describes a central scaffold that predefines the three dimensional structure for diverse molecules linked to this platform. Cyclic β-tripeptides are interesting candidates for use as templates due to their conformationally defined structure, stability to enzymatic degradation, and ability to form intermolecular stacked tubular structur...

INTRODUCTION The use antiretroviral reduces the sexual transmission of HIV, expanding interventions for serodiscordant couples. OBJECTIVE This article aims to review the use of antiretroviral and other prevention interventions among serodiscordant couples and to analyze its use in Brazil. METHODS A retrospective review was performed through the MEDLINE database and bases included in the Bib...

Men's poorer engagement with healthcare generally and HIV care specifically, compared to women, is well-described. Within the HIV public health domain, interest is growing in universal test and treat (UTT) strategies. UTT strategies refer to the expansion of antiretroviral therapy (ART) in order to reduce onward transmission and incidence of HIV in a population, through a "treatment as preventi...

BACKGROUND The Universal HIV Test and Treat (UTT) strategy represents a challenge for science, but is also a challenge for individuals and societies. Are repeated offers of provider-initiated HIV testing and immediate antiretroviral therapy (ART) socially-acceptable and can these become normalized over time? Can UTT be implemented without potentially adding to individual and community stigma, o...

In the spring of 1996, the National Center for Developmental Education (NCDE) was contracted by the Texas Higher Education Coordinating Board (THECB) to conduct an extensive evaluative study of the Texas Academic Skills Program (TASP). The study was completed in October of 1996 and findings were then shared with the Coordinating Board, the Texas Legislature, and Texas public colleges and univer...

Treatment as prevention (TasP) not only stands for prevention of HIV transmission by treating HIV-positives, but also for prevention of morbidity and mortality in those positives. Mathematical models have shown that it should be possible to “eradicate” HIV at the population level, or at least come close to it, if this approach were rigorously applied. But these optimistic models are based on as...