The present work describes a two-wavelength method for simultaneous determination of metoprolol and hydrochlorthiazide in fixed dose combination tablet. The wavelengths selected for method were 257.8 nm, 282.9 nm and 315.0 nm. The absorbance difference at first two wavelengths was used for determination of metoprolol and the latter was used for determination of hydrochlorthiazide. The recovery ...

BACKGROUND Metoprolol, a selective beta-1 blocker, is available in two different salt forms in the market - metoprolol succinate (MS) and metoprolol tartarate (MT). Both the formulations are Food and Drug Administration approved for the treatment of hypertension. Several studies have shown similar efficacies between the two salts; however, they differ in their pharmacokinetic properties and are...

The structure of bovine heart mitochondrial NADH dehydrogenase was investigated by cross-linking constituent subunits with disuccinimidyl tartrate, (ethylene glycol)yl bis(succinimidyl succinate) and dimethyl suberimidate. Cross-linked products were identified by Western blotting with monospecific antisera to nine subunits of the enzyme. Cross-links between subunits within the flavoprotein, iro...

The knowledge of biological trace minerals and phytase requirements for modern broiler genotypes is not established the pressure to reduce their usage in animal feeding due environmental issues increasing. Here, alkaline phosphatase (ALP) tartarate-resistant acid (TRAP) tibia serum broilers fed with diets containing various levels reduced zinc, manganese, copper was evaluated. experiment perfor...

The interactions between Factor B (B), its activation products Ba and Bb, properdin (P) and C3i or C3b, components that together form the alternative-pathway C3 convertase enzyme of human complement, have been analysed. Fluid-phase complexes of the purified components C3i, B and P were probed with the homobifunctional cross-linking reagent disuccinimidyl tartarate, and efficient cross-linking o...

An 80 year old female in good general health was diagnosed with normal tension glaucoma and was prescribed Alphagant (brimonidine tartarate 0.2%) twice daily in both eyes. The intraocular pressure decreased from 15 mmHg to 11 mmHg bilaterally. The patient did not complain of any side effects when using the brimonidine drops. Exactly one year later, she presented with a sudden onset of chemosis,...