Over the past years, emergence of various therapeutic approaches has attracted so much consideration, but chemotherapy remains most effective way in experimental practice. However, due to obstacles and difficulties, there is a limitation for additional clinical presentation outdated chemical treatments such as paclitaxel doxorubicin. Some barriers are severe side effects, profound cytotoxicity,...

Drug delivery across the blood–brain barrier (BBB) has several challenges, especially toward targeting neurological diseases, due to tight and selective function of BBB. Several structural functional components this contribute restricting drug entry, such as interendothelial junctions (TJs), efflux transporters, drug-metabolizing enzymes, crosstalk between cells neurovascular unit. Among differ...