نتایج جستجو برای: targeted gene delivery

تعداد نتایج: 1430970  

Journal: :iranian journal of basic medical sciences 0
reza k. oskuee department of biotechnology, pharmaceutical and biotechnology research centers, school of pharmacy, mashhad university of medical sciences, mashhad, iran ali dehshahri department of biotechnology, pharmaceutical and biotechnology research centers, school of pharmacy, mashhad university of medical sciences, mashhad, iran wayne. t. shier department of medicinal chemistry, university of minnesota-twin cities, minneapolis, mn 55455, usa mohammad ramezani department of biotechnology, pharmaceutical and biotechnology research centers, school of pharmacy, mashhad university of medical sciences, mashhad, iran

objective polyethylenimine (pei), a readily available synthetic polycation which has high transfection efficiency owing to its buffering capacity was introduced for transfection a few years ago. but it has been reported that pei is cytotoxic in many cell lines. in this study, in order to enhance the transfection efficiency of 10 kda pei and reduce its toxicity, hydrophobic residues were grafted...

2017
Na Li Huijun Yang Zhengze Yu Yanli Li Wei Pan Hongyu Wang Bo Tang

Developing effective nonviral siRNA delivery systems for long-term gene silencing remains a great challenge. Here we present a nuclear-targeted siRNA delivery system that can induce long-term gene silencing in cancer cells. The nanocarrier consists of gold nanoparticles modified with a dense shell of synthetic siRNAs and nuclear localization signal (NLS) peptides. The NLS peptide could transloc...

Journal: :Chemical and Pharmaceutical Bulletin 2005

Journal: :iranian biomedical journal 0
محمد رضا صدایی m. reza sadaie سروش آریا suresh k. arya

lentiviral vectors are promising gene delivery tools capable of transducing a variety of dividing and non-dividing cells, including pluripotent stem cells which are refractory for transduction by murine retroviruses. although there is a growing debate on the safety of lentiviral vectors for gene transfer, in particular for those derived from human immunodeficiency viruses, type one (hiv-1) and ...

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