Currently, intelligent, responsive biomaterials have been widely explored, considering the fact that provide controlled and predictable results in various biomedical systems. Responsive nanostructures undergo reversible or irreversible changes presence of a stimulus, stimuli can be temperature, magnetic field, ultrasound, pH, humidity, pressure, light, electric etc. Different types being used d...

Targeted drug delivery or site-specific drug delivery system has the potential to increase local drug concentrations and thereby increase the effectiveness of the medicines with fewer side effects. Liver diseases especially liver cancer is one of the most prevalent cancers, with a high mortality. Due to high toxicity and poor specificity of the chemotherapeutic agents the present method of trea...

Aptamers are a class of therapeutic oligonucleotides that form specific three-dimensional structures that are dictated by their sequences. They are typically generated by an iterative screening process of complex nucleic acid libraries employing a process termed Systemic Evolution of Ligands by Exponential Enrichment (SELEX). SELEX has traditionally been performed using purified proteins, and c...

Targeted drug delivery to specific group of cells offers an attractive strategy to minimize the undesirable side effects and achieve the therapeutic effect with a lower dose. Both linear and cyclic peptides have been explored as trafficking moiety due to ease of synthesis, structural simplicity, and low probability of undesirable immunogenicity. Peptides derived from sequence of cell surface pr...

Kidney-targeted drug delivery systems represent a promising technology to improve drug efficacy and safety in the treatment of renal diseases. In this review, we summarize the strategies that have been employed to develop kidney-targeted drug delivery systems. We also describe how macromolecular carriers and prodrugs play crucial roles in targeting drugs to particular target cells in the kidney...

pluronic based nano-particulate systems are innovative platforms for delivery of anti-cancer agents. these systems due to their pharmacological properties and suitable physicochemical characteristics are great opportunity for development cancer therapeutics. this mini-review tries to provide a more detailed overview on the currently available pluronic based drug delivery systems. in the section...

Smart drug delivery system (SDDS) is a recently emerging therapeutic approach, now turning into a conventional model to deliver drug to specific sites or target. Drug tar‐ geted (DT) delivery systems maintain the concentration of the drugs at desirable doses in the body and avoid the need for repeated doses. The DT delivery system have specific distinguishing features such as self-regulated, pr...