As a necessary process of modern drug development, finding compound that can selectively bind to specific protein is highly challenging and costly. Exploring drug-target interaction strength in terms affinity (DTA) an emerging effective research approach for development. However, it model interactions deep learning manner, few studies provide interpretable analysis models. This paper proposes D...

Diminishing protein aggregation by chaperone is very important factor in medicine and industry. In this paper, itis induced the chaperone ability for 0-casein upon modification of its acidic residues by Woodward reagentK(WRK) and examined on lysozyme as a target protein at pH 7.2 and outlined the mechanism for chaperoneability of modified system by UV-Vis and fluorescence spectroscopy and theor...

We demonstrate a prototype that translates schemas from a source metamodel (e.g., OO, relational, XML) to a target metamodel. The prototype is integrated with Microsoft Visual Studio 2005 to generate relational schemas from an object-oriented design. It has four novel features. First, it produces instance mappings to round-trip the data between the source schema and the generated target schema....

Antibody-drug conjugates are targeted anticancer agents consisting of a cytotoxic drug covalently linked to a monoclonal antibody for tumor antigen-specific activity. Once bound to the target cell-surface antigen, the conjugate must be processed to release an active form of the drug, which can reach its intracellular target. Here, we used both biological and biochemical methods to better define...

In this paper, we introduce a moving target defense mechanism that defends authenticated clients against Internet service DDoS attacks. Our mechanism employs a group of dynamic, hidden proxies to relay traffic between authenticated clients and servers. By continuously replacing attacked proxies with backup proxies and reassigning (shuffling) the attacked clients onto the new proxies, innocent c...