Secondary metabolites from plants are a good source for the NSAID drug development. We studied the analgesic activity of ethanolic extract of Erythrina variegata L. (Fabaceae) followed by molecular docking analysis. The analgesic activity of Erythrina variegata L. is evaluated by various methods viz., acetic acid-induced writhing test, hot plate and tail immersion test. Subsequently, molecular ...

Tail-biting is an abnormal behavior of multifactorial origin, that consists a major problem in modern pig industry. It has serious impact on both welfare and health status the pigs involved, as well economic profitability farm. considered to be adaptation poor environment triggered by plethora external internal risk factors interacting with each other. A great variation exists prevalence tail b...

The European Convention for the Protection of Pet Animals was opened for signature in Strasbourg on 13 November 1987 and entered into force on 1 May 1992. This Convention states that: 'Surgical operations for the purpose of modifying the appearance of a pet animal or for other non-curative purposes shall be prohibited and, in particular: the docking of tails'. At present, 15 of the 27 States in...

The 3-amino-2-methylpyridine derivative 1 was identified as ligand of the BAZ2B bromodomain by automatic docking of nearly 500 compounds, selected on the basis of previous fragment hits. Hit expansion by two in silico approaches, pharmacophore search followed by docking, and substructure search resulted in five additional ligands. The predicted binding mode of the six 3-amino-2-methylpyridine d...

Farmers claim that they need to tail-dock their piglets in order to stop them from biting each other’s tails. When part of the tail is docked, the remaining tail is very sensitive to touch or oral manipulation (SVC, 1997). As a result, a pig with a docked tail will move away much more quickly from an attempt at tail-biting than a pig with an intact tail, and will thereby prevent its tail being ...

Histone tail acetylation is a key epigenetic marker that tends to open chromatin folding and activate transcription. Despite intensive studies, precise roles of individual lysine acetylation in chromatin folding have only been poorly understood. Here, we revealed structural dynamics of tri-nucleosomes with several histone tail acetylation states and analyzed histone tail interactions with DNA b...