Gastro-oesophageal reflux is a common clinical disorder associated with a variety of respiratory symptoms, including chronic cough and exacerbation of asthma. In this study, the potential role of acid-induced tachykinin release was examined in guinea pigs and rabbits, by examining the effects of the tachykinin NK1 and NK3 receptors antagonists (SR 140333 and SR 142801, respectively) (1-10 mg x ...

2 3 Endocannabinoids mediate tachykinin induced effects in the lamprey locomotor 4 network 5 6 7 8 9 10 11 Carolina Thörn Pérez, Russell H. Hill, Abdeljabbar El Manira, Sten Grillner 12 Nobel Institute for Neurophysiology 13 Department of Neuroscience, Karolinska Institutet, 14 SE17177 Stockholm, Sweden 15 16 Running head: Endocannabinoids mediate tachykinin effects 17 18 19 20 21 Corresponding...

Tachykinin neuropeptides, such as substance P, are localized to a population of sensory fibers that innervate the mammalian female reproductive tract. In the present study, we have characterized tachykinin NK1 receptor (NK1R), NK2 receptor (NK2R), and NK3 receptor (NK3R) gene expression by semiquantitative RT-PCR in uteri from ovariectomized rats and studied their regulation in response to 17be...

1 Extraction, Biological Testing and Structural Elucidation . . . . . . . . . . . . 1 2 Masanori Otsuka and the Action of Substance P in the Spinal Cord . . . . . . 8 3 Radioimmunoassay and Immunohistochemistry of Substance P . . . . . . . . 8 4 Nicolas Jancs and Capsaicin . . . . . . . . . . . . . . . . . . . . . . . . . . . . 10 5 Peptide and Nonpeptide Transmitters in Primary Afferent Neuron...

We previously demonstrated that exogenously administered neurokinin A and neurokinin B, but not substance P, increased the sensitivity of cultured cerebellar granule neurons (CGNs) to glutamate. In the present study, the presence of tachykinin neuropeptides in CGNs was tested by confocal-based immunofluorescence. We found that neurokinin A and neurokinin B are present in CGNs but absent in astr...

BACKGROUND Acid reflux may aggravate airway disease including asthma and chronic cough. One postulated mechanism concerns a vagally-mediated oesophageal-tracheobronchial reflex with airway sensory nerve activation and tachykinin release. AIM To test the hypothesis that patients with airways disease and reflux have higher airway tachykinin levels than those without reflux. METHODS Thirty-two...