Strontium ranelate is a relatively new drug used as a second-line treatment for osteoporosis, often targeted at older patients. It is known to cause skin rash and rarely drug reaction with eosinophilia and systemic symptoms, but there are no reports of exfoliative dermatitis as a reaction in the literature. We present the first two cases of this adverse effect of the drug, combined with eosinop...

DRESS: drug reaction with eosinophilia and systemic symptoms RegiSCAR: Registry of Severe Cutaneous Adverse Reactions INTRODUCTION Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a life-threatening adverse drug reaction with an up to 10% mortality rate. It is characterized by fever, skin eruption, lymphadenopathy, and systemic organ dysfunction. Aromatic anticonvulsant...

CMV: cytomegalovirus DIHS: drug-induced hypersensitivity syndrome DRESS: drug reaction with eosinophilia and systemic symptoms HHV: human herpesvirus WBC: white blood cell INTRODUCTION Drug-induced hypersensitivity syndrome (DIHS)/ drug reaction with eosinophilia and systemic symptoms (DRESS) is a severe adverse systemic reaction. DIHS is characterized by its limited number of causative drugs, ...

In this study, we compared a purified aqueous extract and the corresponding nonpurified aqueous preparation under the same build-up protocol in bee venom allergic patients with a normal baseline mast cell tryptase concentration. Eighty patients with a history of a systemic reaction were enrolled for immunotherapy using a 5-day rush protocol. Patients treated with the purified extract and those ...

Abstract A 46-year-old man was referred for investigation of an acute widespread rash and fever that started 4 weeks after commencing citalopram. Clinical histological features were consistent with drug reaction eosinophilia systemic (DRESS). He not on any other medication, had no known allergies previously taken a selective serotonin reuptake inhibitor (SSRI). Six months resolution, he patch t...

44 Serum sickness classically refers to a systemic immunological reaction caused by injected serum and occurs due to deposition of an antigen-antibodycomplement complex. It occurs when an antigen (i.e. serum) persists in the circulation for a long duration stimulating IgG or IgM antibody synthesis. These antibodies, along with complement, form complexes which are deposited in various organs. Th...

Drug reaction with eosinophilia and systemic symptoms (DRESS) is a severe cutaneous adverse involving multiorgan failure, complex interaction of various drugs, human herpesvirus reactivation immune abnormalities suggested as the aetiology. We herein present case 70-year-old man one-week history fever, facial oedema, erythematous macules purpura on his trunk extremities. He had anti-TIF1γ antibo...