The synthesis of a series of purine analogues of the acyclonucleoside compound 14 (acyclovir) is described. Compounds in this series have been shown to have pronounced activity against herpes virus-type l(HSV-1). The anti-viral activities of other analogs whose syntheses were recently reported [1] by us are also described

An efficient, mild and environmentally friendly method was developed for the Strecker reaction to synthesize α-aminonitriles in the presence of methyl imidazolium hydrogen sulfate ([Hmim][HSO4]) as an efficient catalyst. These syntheses were performed via a one-pot three-component condensation of aldehydes (or ketones), amines, and trimethylsilyl cyanide under mild and solvent free c...

This paper examines the molecular mechanism of InP colloidal quantum dot (QD) syntheses. Unlike methods for monodisperse PbSe and CdSe we found that existing InP syntheses result in total depletion of molecular phosphorous species following nucleation, so QD growth is due exclusively to non-molecular ripening. We find that amines inhibit precursor depletion via solvation, and these findings may...

2.1.1. Syntheses of alkali metal ozonides 51 2.1.2. Crystal structures of alkali metal ozonides 53 2.1.2.1. Potassium ozonide 53 2.1.2.2. Rubidium ozonide 56 2.1.2.3. Cesium ozonide 57 2.1.3. Thermal properties and decomposition of K0 3 ,Rb0 3 , andCs03 57 2.1.4. Magnetic properties of K0 3 ,Rb0 3 , and Cs0 3 57 2.1.5. Spectroscopic properties of ionic ozonides 58 2.2. Further ozonides 59 2.2.1...

Short and efficient syntheses of coronarin E (4) and chinensines A-E (5-9) have been accomplished. The use of two different types of reaction of singlet oxygen ((1)O(2)) lies at the heart of the synthetic strategy. The syntheses have facilitated the clarification of certain previously unknown, or unconfirmed, stereochemical details (the relativity stereochemistries of chinensines D and E and th...

Enantioselective syntheses of the alkaloids (-)-aurantioclavine, (+)-amurensinine, (-)-lobeline, and (-)- and (+)-sedamine are described. The syntheses demonstrate the effectiveness of the Pd-catalyzed asymmetric oxidation of secondary alcohols in diverse contexts and the ability of this methodology to set the absolute configuration of multiple stereocenters in a single operation. The utility o...

Because of the highly unique structures of marine natural products, there are many examples of structures that were originally proposed based on spectral analyses but later proven incorrect. In many cases, the total syntheses of the originally proposed structures of marine natural products has confirmed their incorrectness and the subsequent total syntheses of the newly proposed structures prov...