Associative synaptic plasticity is synapse specific and requires coincident activity in pre-synaptic and post-synaptic neurons to activate NMDA receptors (NMDARs). The resultant Ca(2+) influx is the critical trigger for the induction of synaptic plasticity. Given its centrality for the induction of synaptic plasticity, a model for NMDAR activation incorporating the timing of pre-synaptic glutam...

Glutamate is the most important excitatory neurotransmitter in the central nervous system which is involved in synaptic transmission, brain development, synaptic plasticity, learning, and memory. Normally, the enzymatic destruction of glutamate does not occur in the synaptic and extracellular space, but glutamate is removed through specific transporter proteins, leading to stabilization of glut...

Homeostatic synaptic plasticity is a form of non-Hebbian plasticity that maintains stability of the network and fidelity for information processing in response to prolonged perturbation of network and synaptic activity. Prolonged blockade of synaptic activity decreases resting Ca(2+) levels in neurons, thereby inducing retinoic acid (RA) synthesis and RA-dependent homeostatic synaptic plasticit...

Synaptic plasticity is activity-dependent modification of the efficacy of synaptic transmission. Although, detailed mechanisms underlying synaptic plasticity are diverse and vary at different types of synapses, diacylglycerol (DAG)-associated signaling has been considered as an important regulator of many forms of synaptic plasticity, including long-term potentiation (LTP) and long-term depress...

background: cyclooxygenase (cox) enzyme known as a regulatory factor in synaptic plasticity. it has been reported that synaptic plasticity is one of the mechanisms involved in learning and memory processes. in the current study peripheral injection's effects of sodium salicylate (as a non selective cox inhibitor) on spatial learning and memory have been investigated. methods: four groups of mal...