Parkinson’s disease (PD) is a movement disorder characterized by the appearance of inclusions known as Lewy bodies, most prominently in the substantia nigra pars compacta. The synaptic protein α-synuclein (α-syn) and polyubiquitin are major components of Lewy bodies. The objective of this study was, firstly, to evaluate whether α-syn inhibits proteolytic function of the proteasome and, secondly...

Synucleins (Syn), a family of synaptic proteins, includes alpha-Syn, which plays a pivotal role in Parkinson's disease and related neurodegenerative diseases (synucleinopathies) by forming distinct brain pathologies (Lewy bodies and neurites). Since traumatic brain injury (TBI) is a poorly understood risk factor for Parkinson's disease, we examined the effects of TBI in the young and aged mouse...

This draft specifies a modification to RFC 3168 to allow TCP SYN/ACK packets to be ECN-Capable. For TCP, RFC 3168 only specifies setting an ECN-Capable codepoint on data packets, and not on SYN and SYN/ACK packets. However, because of the high cost to the TCP transfer of having a SYN/ACK packet dropped, with the resulting retransmit timeout, this document specifies the use of ECN for the SYN/AC...

Crematogaster ants are diverse, widespread and abundant in tropical, subtropical and warm-temperate climates throughout the world. The species diversity of this genus has been notoriously difficult to manage based upon morphology alone, and former attempts have generated a vaguely defined subgeneric system. I propose an improvement of the previous subgeneric classification and recognize two sub...

Nine 5-bromodeoxyuridine-induced temperature-sensitive (ts) mutants were isolated from stocks of a syncytial plaque type mutant (syn) itself derived from the non-syncytial wild-type (syn +) of the GLASGOW strain i7 of herpes simplex virus type i. The nine ts mutants have been assigned to eight cistrons on the basis of different complementation tests. Non-syncytial revertants isolated from the o...

Abnormal folding of -synuclein ( -syn) is thought to lead to neurodegeneration and the characteristic symptoms of Lewy body disease (LBD). Since previous studies suggest that immunization might be a potential therapy for Alzheimer’s disease, we hypothesized that immunization with human (h) -syn might have therapeutic effects in LBD. For this purpose, h syn transgenic (tg) mice were vaccinated w...

The proposal in this document is Experimental. While it may be deployed in the current Internet, it does not represent a consensus that this is the best possible mechanism for the use of Explicit Congestion Notification (ECN) in TCP SYN/ACK packets. This document describes an optional, experimental modification to RFC 3168 to allow TCP SYN/ACK packets to be ECN-Capable. For TCP, RFC 3168 specif...

Cytoplasmic inclusions containing alpha-synuclein (alpha-Syn) fibrils, referred to as Lewy bodies (LBs), are the signature neuropathological hallmarks of Parkinson's disease (PD). Although alpha-Syn fibrils can be generated from recombinant alpha-Syn protein in vitro, the production of fibrillar alpha-Syn inclusions similar to authentic LBs in cultured cells has not been achieved. We show here ...

Mutations in -synuclein ( -Syn) cause Parkinson’s disease (PD) in a small number of pedigrees with familial PD. Moreover, -Syn accumulates as a major component of Lewy bodies and Lewy neurites, intraneuronal inclusions that are neuropathological hallmarks of PD. To better understand the pathogenic relationship between alterations in the biology of -Syn and PD-associated neurodegeneration, we ge...

Abnormal α-synuclein (α-syn) accumulation in the CNS may underlie neuronal cell and synaptic dysfunction leading to motor and cognitive deficits in synucleinopathies including Parkinson's disease (PD) and Dementia with Lewy Bodies (DLB). Multiple groups demonstrated α-syn accumulation in CNS accessory structures, including the eyes and olfactory terminals, as well as in peripheral organs of Par...