Egr3 is a nerve growth factor (NGF)-induced transcriptional regulator that is essential for normal sympathetic nervous system development. Mice lacking Egr3 in the germline have sympathetic target tissue innervation abnormalities and physiologic sympathetic dysfunction similar to humans with dysautonomia. However, since Egr3 is widely expressed and has pleiotropic function, it has not been clea...

Sympathetic axons use blood vessels as an intermediate path to reach their final target tissues. The initial contact between differentiating sympathetic neurons and blood vessels occurs following the primary sympathetic chain formation, where precursors of sympathetic neurons migrate and project axons along or toward blood vessels. We demonstrate that, in Ret-deficient mice, neuronal precursors...

Our previous studies have shown that the cardiac sympathetic afferent reflex is enhanced in rats with chronic heart failure (CHF) induced by coronary artery ligation and contributes to the over-excitation of sympathetic activity. We sought to determine whether sympathetic activity and cardiac sympathetic afferent reflex were enhanced in adriamycin-induced CHF and whether angiotensin II (Ang II)...

AIM OF REVIEW Many chronic pain conditions remain difficult to treat, presenting a high burden to society. Conditions such as complex regional pain syndrome may be maintained or exacerbated by sympathetic activity. Understanding the interactions between sympathetic nervous system and sensory system will help to improve the effective management of pathological pain including intractable neuropat...

sheep as an experimental animal has been used in many veterinary researches. the developmental study of the ovine cervicothoracic ganglion in the fetal stages will reveal the anatomy of the sympathetic nervous system in the adult sheep and morphological and morphometrical relation between this ganglion and surrounding structures. the aim of this research was to follow morphological and morphome...

results all variables reached a peak at 1 minute post-jump. salivary alpha-amylase, galvanic skin responses and heart rate did not return to basal value at 90 minutes post-jump, while cortisol returned to basal value at 90 minutes post-jump. conclusions this evidence indicates that parachute jumping is accompanied by a dissociation of sns and hpa response patterns in novice parachutists, showin...

There is growing evidence that essential hypertension is commonly neurogenic and is initiated and sustained by sympathetic nervous system overactivity. Potential mechanisms include increased central sympathetic outflow, altered norepinephrine (NE) neuronal reuptake, diminished arterial baroreflex dampening of sympathetic nerve traffic, and sympathetic neuromodulation by angiotensin II. To addre...

The topic of human relationships—be they positive and sympathetic, or negative and hostile—receives a great amount of attention in the Qur’ān. Human beings need to be aware of both their friends and their enemies in order to learn how to engage with both groups, how to make additional friends and defend themselves from harm caused by enemies, and, if possible, turn these enemies into friends. T...