Protein arginine methyltransferases (PRMTs), an emerging target class in drug discovery, can methylate histones and other substrates, and can be divided into three subgroups, based on the methylation pattern of the reaction product (monomethylation, symmetrical or asymmetrical dimethylation). Here, we review the growing body of structural information characterizing this protein family, includin...

INTRODUCTION Denervation of the paraspinal muscles in spinal disorders is frequently attributed to radiculopathy. Therefore, patients with lumbar spinal stenosis causing asymmetrical symptoms should have asymmetrical paraspinal denervation. METHODS Seventy-three patients with clinical lumbar spinal stenosis, aged 55-85 years, completed a pain drawing and underwent masked electrodiagnostic tes...

normal 0 false false false en-us x-none ar-sa microsoftinternetexplorer4 background: diabetes mellitus is one of the most important epidemics of our era. complications of this disease are diverse and include retinopathy, nephropathy and neuropathy. this study has been designed to evaluate hearing loss patterns in young children suffering from iddm and define risk factors for this complication. ...