The PHR (Pam/Highwire/RPM-1) family of ubiquitin E3 ligases plays conserved roles in axon patterning and synaptic development. Genetic modifier analysis has greatly aided the discovery of the signal transduction cascades regulated by these proteins. In Caenorhabditis elegans, loss of function in rpm-1 causes axon overgrowth and aberrant presynaptic morphology, yet the mutant animals exhibit lit...

During development, neural activity is important for forming proper connections in neural networks. The effect of activity on the gross morphology and synaptic strength of neurons has been well documented, but little is known about how activity affects different molecular components during development. Here, we examine the localization of four fluorescently-tagged presynaptic proteins, RAB-3, S...

Tying web services together to build large, distributed, collaborative applications has gathered noticeable momentum and a lot of research is being put in it. Along with composition of the web services, coordination is one key aspect that has been considered keenly. Many frameworks, languages and protocols have been proposed for web service composition and coordination. With the advancement in ...

A permeability prediction model for relaxed and sheared Non-Crimp Fabrics is proposed. The model is based on geometrical features of the fabric. The stitches penetrating the uni-directional plies of the NCF induce distortions of the fibres in the plane of the fabric. These Stitch Yarn induced fibre Distortions (SYD) form flow channels, which determine the permeability of the NCF. The channels a...

Today’s web applications are more collaborative and are using the standard and ubiquitous Internet protocols. We have earlier developed System on Mobile Devices (SyD) middleware to rapidly develop and deploy collaborative applications over heterogeneous and possibly mobile devices hosting web objects. In this paper, we present the software engineering methodology for developing SyD-enabled web ...

This paper presents a fleet management application with heterogeneity of devices and data, database synchronization, group transactions, peer-to-peer computing, and mobility support. We simulate a delivery service's fleet of trucks with PCs and hand-held devices, and describe how the system works together. To send messages between devices, we use the Simple Object Access Protocol (SOAP), allowi...