BACKGROUND Interleukins (IL) play an important role in angiogenesis. Tocopherol possesses immunomodulating effect in addition to antioxidant property. The objective of this study was to determine whether gamma tocopherol's (gT) angiogenic activity in placental network is enhanced via promoting interleukins. METHODS Pregnant ewes (N=18) were supplemented, orally, with 500 mg of alpha tocophero...

In primary analysis from the TRUSTY study, trifluridine/tipiracil (FTD/TPI) plus bevacizumab (BEV) failed to show non-inferiority in terms of overall survival (OS) irinotecan and fluoropyrimidine BEV as second-line treatment patients (pts) with metastatic colorectal cancer (mCRC) who first-line chemotherapy oxaliplatin either or an anti-EGFR antibody (median OS: 14.8 vs. 18.1 months; hazard rat...