نتایج جستجو برای: survivin antisense
تعداد نتایج: 19309 فیلتر نتایج به سال:
RNA interference (RNAi) has become a powerful technique for studying gene function, biological pathways, and the physiology of diseases. Typically, the RNAi response in mammalian cells is mediated by small interfering RNA (siRNA). The use of synthesized siRNA to silence gene is relatively quick and easy, but it is costly with transient effects. A short hairpin RNA (shRNA) with complementary sen...
We present an untemplated, single-component antisense oligonucleotide delivery system capable of regulating mRNA abundance in live human cells. While most approaches to nucleic acid delivery rely on secondary carriers and complex multicomponent charge-neutralizing formulations, we demonstrate efficient delivery using a simple locked nucleic acid (LNA)-polymer conjugate that assembles into spher...
abstract background and aim: survivin is a new member of inhibitor of apoptosis protein family (iap) that plays an important role in the regulation of cell cycle and inhibition of apoptosis. distinct expression of this gene in tumoral cells versus normal cells introduces it as the fourth major transcriptome in cancers. thyroid carcinoma is the most common endocrine malignancy. considering the h...
Introduction & Objective: Survivin is one of the new characterized members of the inhibitor of apoptosis proteins that shows widespread expression in embryonic and tumoric tissues. The aim of this study was to evaluate the expression of Survivin variants in different stages of follicular development in mouse ovary. Materials & Methods: This experimental study was carried out on immature fema...
Introduction: Survivin gene, as an apoptosis inhibitor, plays an important role in development of breast cancer. The differential expression of survivin in cancer versus normal adult cells as well as an association between high expression of survivin and aggressive tumors has led to use of survivin as a molecular marker for diagnosis and prognosis of tumors. The underlying mechanism of survivin...
Introduction: Survivin is a new member of the Inhibitor Apotosis Protein family (IAP) which plays an important role in the regulation of both cell cycle and apoptosis. Its distinct expression in tumor cells as compared to normal adult cells introduces Survivin as the fourth transcriptom demonstrated in tumors. Breast cancer is the most common malignancy among women and scientist`s efforts to cl...
survivin عضوی از خانواده ی پروتئین های مهار کننده ی آپاپتوز (iap) محسوب می شود که بیان متفاوتی از آن در سلول های نرمال و سرطانی گزارش شده است. افزایش بیان survivin باعث مهار آپاپتوز، افزایش پیشرفت تومور و مقاومت به شیمی درمانی می شود. نقش survivin در بقا و تقسیم سلولی و تفاوت بیان آن در سلول های نرمال و سرطانی، این پروتئین را به یک مارکر تشخیصی و هدف درمانی تبدیل کرده است. امروزه به علت همراهی ...
Received: 22 Sep, 2012 Accepted: 18 Des, 2012 Background & Aims : Chronic myeloid leukemia (CML) is a hematopoietic malignancy in which chromosomal translocation is involved in indefinite proliferation and resistance to apoptosis. It has been showed that survivin over-expression is associated with poor prognosis and poor response to chemotherapy of leukemia patients. However, there is no co...
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