in this paper, we have outlined the surrogate management framework for optimization of expensive functions. an initial simple iterative method which we call the “strawman” method illustrates how surrogates can be incorporated into optimization to stand in for the most expensive function. these ideas are made rigorous by incorporating them into the framework of pattern search methods. the smf al...

dibutyl phthalate (dbp) is a phthalic acid ester and is widely used in polymeric products to make them more flexible. dbp is found in almost every plastic material and is believed to be persistent in the environment. various analytical methods have been used to measure dbp in different matrices. considering the ubiquitous nature of dbp, the most important challenge in dbp analyses is the contam...

This paper reviews research findings on caretaking-related problems associated with the absence of parents from the home following incarceration. It focuses on the impact of incarceration on the welfare and adjustment of urban African American children and on the assumption of caretaking responsibilities by other caretakers, principally maternal grandmothers. Noting the complex situational diff...

In Ex parte JCR 2022 5 SA 202 (GP) the Pretoria High Court per Neukircher J seeks to introduce new requirements for all surrogacy agreements in South African law. The court considered psychological impact of on children both surrogate parents and commissioning need put place procedures ‘for preparing them this process [of not bringing baby home]’ or a addition their family’, respectively. order...

The present commentary analyses and discusses the Fjölnisdóttir et al. v. Iceland decision of European Court Human Rights (ECtHR) 18 May 2021. case concerned an Icelandic couple who had been recognised as legal parents a child born by surrogate mother in California. In contrast to most other surrogacy cases decided ECtHR, however, no biological link either intended parents. ECtHR thus found tha...

This short chapter introduces the SURROGATE data type, which is useful when modeling time-varying objects. Surrogates are unique identifiers that can be compared for equality, but the values of which cannot be seen by the users. In this sense, a surrogate is “pure” identity and does not describe a property (i.e., it has no observable value). For this reason, a SURROGATE data type cannot be trea...

nonlinear knapsack problems (nkp) are the alternative formulation for the multiple-choice knapsack problems. a powerful approach for solving nkp is dynamic programming which may obtain the global op-timal solution even in the case of discrete solution space for these problems. despite the power of this solu-tion approach, it computationally performs very slowly when the solution space of the pr...

A special class of the knapsack problem is called the separable nonlinear knapsack problem. This problem has received considerable attention recently because of its numerous applications. Dynamic programming is one of the basic approaches for solving this problem. Unfortunately, the size of state-pace will dramatically increase and cause the dimensionality problem. In this paper, an efficient a...

STUDY QUESTION How do the psychological health and experiences of surrogate mothers change from 1 year to 10 years following the birth of the surrogacy child? SUMMARY ANSWER The psychological well-being of surrogate mothers did not change 10 years following the birth, with all remaining positive about the surrogacy arrangement and the majority continuing to report good mental health. WHAT I...

Genomic sequencing is being rapidly introduced into pediatric clinical practice. The results of sequencing are distinctive for their complexity and subsequent challenges of interpretation for generalist and specialist pediatricians, parents, and patients. Pediatricians therefore need to prepare for the professionally responsible disclosure of sequencing results to parents and patients and guida...