The residue levels of selected fluoroquinolones, sulfonamides and tetracyclines in 143 animal dung samples collected in 2007 from large-scale livestock and poultry feedlots in 8 provinces were determined by using ultrasonic extraction and liquid chromatography. Recoveries from spiked pig dung samples (spike level=1mg/kg) ranged from 73.9 to 102.0% for fluoroquinolones, from 81.6 to 92.3% for su...

Abstract Water pollution is referred to as the introduction of exotic species into an ecosystem, which poses serious difficulties for both environment and human health. As a result, water treatment has garnered lot interest in recent studies, particularly dyes removal. In effort synthesize new photocatalysts with highest potential removing pollutants, photocatalytic degradation two types dyes; ...

Vibrio bacteria, particularly members of the Harveyi clade, are most important pathogens aquatic organisms that cause significant economic losses in world. It is difficult to provide specific data on taxa clade for biological research and prevention strategies. Therefore, we conducted an extensive phenotypic antibiotic resistance study, as well phylogenetic molecular typing 192 isolates collect...

The objectives of this study were to evaluate the ability of 14 compounds, which differentially activate human pregnane X receptor (hPXR), to induce CYP2B6 expression and to compare CYP2B6 and CYP3A4 concentration- and time-dependent induction by select inducers. Three primary human hepatocyte preparations were treated daily for 3 days with three concentrations of all compounds. Additional conc...

In previous papers we demonstrated that cyclosporin A (CsA) was specifically oxidized in rabbit and human liver by cytochrome P-45OIIIA. We therefore anticipated that any drug that is an inducer or an inhibitor of this cytochrome should lead to interaction with CsA when given in association with it. In order to confirm this hypothesis, primary cultures of human hepatocytes and human liver micro...

Amantadine acetylation was demonstrated to occur both in vivo and in vitro using transgenic male mice overexpressing spermidine/spermine N-acetyltransferase (SSAT). We previously reported that neither NAT1 nor NAT2 was responsible for catalyzing acetylation of the primary amine group of amantadine. We hypothesized that the inducible polyamine-catabolizing enzyme, SSAT, was an alternate pathway ...