a Laboratoire d’Étude et Modélisation des Environnements Littoraux (Lemel), Université de Bretagne Sud, Centre Yves Coppens, Campus de Tohannic, F-56000, Vannes. b Laboratoire de Statistiques Appliquées de BREtagne Sud (Sabres), Université de Bretagne Sud, Centre Yves Coppens, Campus de Tohannic, F-56000, Vannes. c Laboratoire de Mathématiques et Applications des Mathématiques (LMAM) , Universi...

OBJECTIVE To evaluate the mediating/moderating effects of common internalizing /externalizing disorders on the association between ADHD and adolescent substance use disorders (SUD) in a population-based birth cohort. METHODS Among 5718 children in the birth cohort, 343 ADHD incident cases and 712 matched controls were identified. Psychiatric diagnoses prior to age 19 were classified into DSM-...

We longitudinally investigated coping among male military veterans (n = 98) with posttraumatic stress disorder (PTSD) symptomatology and a co-occurring substance use disorder (SUD) who participated in a randomized controlled trial of seeking safety (SS). Participants were randomized to SS or intensive treatment-as-usual (TAU) for SUD. Coping (active, avoidant, emotional discharge), and PTSD and...

Highly pathogenic severe acute respiratory syndrome coronavirus (SARS-CoV) has developed strategies to inhibit host immune recognition. We identify cellular E3 ubiquitin ligase ring-finger and CHY zinc-finger domain-containing 1 (RCHY1) as an interacting partner of the viral SARS-unique domain (SUD) and papain-like protease (PL(pro)), and, as a consequence, the involvement of cellular p53 as an...

1 Neurocritical Care Unit, Centre Hospitalier Universitaire Sud Réunion, Saint-Pierre, France, 2 Department of Neurosurgery, Centre Hospitalier Universitaire Sud Réunion, Saint-Pierre, France, 3 INSERM, UMR 1188 Diabète athérothrombose Thérapies Réunion Océan Indien (DéTROI), plateforme CYROI, Sainte Clotilde, France, 4 Centre d’Études Périnatales de l’Océan Indien (CEPOI) – EA 7388, Centre Hos...

OBJECTIVE To assess the risk for substance use disorders (SUD) associated with previous exposure to psychotropic medication in a longitudinal study of boys with attention-deficit/hyperactivity disorder (ADHD). METHODS The cumulative incidence of SUD throughout adolescence was compared in 56 medicated subjects with ADHD, 19 nonmedicated subjects with ADHD, and 137 non-ADHD control subjects. ...

Substance use disorder (SUD) is associated with ADHD. ADHD increases the severity of SUD and has negative influence on the prognosis of the disorder. The aim of the study was to determine the prevalence and correlates of ADHD in individuals with SUD. During 2013-2015, a cross-sectional descriptive study of 233 drug treatment-seeking individuals was assessed. Diagnosis of ADHD was done using DSM...

Background: Many health care systems track the HEDIS measures of Initiation and Engagement in substance use disorder (SUD) care. However, the impacts of setting of care (inpatient vs. outpatient) and health care specialty (SUD, psychiatric, other) on the likelihood of patients meeting the Initiation and Engagement criteria are unknown. If the vast majority of Initiation and Engagement occurs wi...

AIMS This study evaluated the primary/secondary distinction among substance misusers according to comorbid mental disorders. METHODS A consecutive sample (n = 287) of DSM-IV substance dependents from public treatment facilities in two counties in Norway were assessed by the Composite International Diagnostic Interview. According to the debut of the first independent mental disorder, patients ...

OBJECTIVES Previous research identified alexithymia as a potential risk factor for substance use disorders (SUD). More insight into the relation between alexithymia and SUD is needed in order to treat SUD effectively. Therefore, we investigated whether a familial vulnerability to alcoholism relates to the presence and severity of alexithymia in SUD patients. METHOD Hospitalized, abstinent SUD...