We assessed the pharmacokinetics and interaction of ABT-773 in 12 volunteers receiving ABT-773 alone or concomitantly with ranitidine or sucralfate. Data for 150 mg of ABT-773 were as follows: the maximum concentration of the drug in plasma (C(max)) was 318 ng/ml, its half-life was 5.66 h, and its area under the plasma concentration-time curve from 0 h to infinity (AUC(0- infinity )) was 1,662 ...

We report a case of an 85-year-old woman who presented with acute respiratory failure, caused by aspirating a sucralfate tablet that totally occluded her left main-stem bronchus. Acute respiratory failure resolved after bronchoscopic removal of the markedly expanded tablet. To our knowledge, the acute obstruction of a main-stem bronchus by an aspirated foreign body has not been previously descr...

IMPORTANCE Postoperative sore throat is one of the most common problems after tonsillectomy. Antibiotics remove the local flora and reduce inflammation and thus may reduce postoperative pain after tonsillectomy. OBJECTIVE To assess the effect of topical sucralfate and clindamycin on local pain reduction after tonsillectomy in children aged 6 to 12 years. DESIGN, SETTING, AND PARTICIPANTS Tr...

The effects of food and sucralfate on the pharmacokinetics of levofloxacin following the administration of a single 500-mg oral dose were investigated in a randomized, three-way crossover study with young healthy subjects (12 males and 12 females). Levofloxacin was administered under three conditions: fasting, fed (immediately after a standardized high-fat breakfast), and fasting with sucralfat...

Esophageal intramural pseudodiverticulosis (EIPD) is a rare condition often presenting with esophageal strictures. Treatment is often limited to endoscopic dilatation and treatment of the underlying esophageal pathology. We present a case of a patient with longstanding GERD on famotidine (she experienced anaphylaxis with proton pump inhibitors [PPIs]) who presented with dysphagia and weight los...

     Acidic pH of stomach, which is a normal physiological barrier against bacterial overgrowth, would increase by stress ulcer prophylaxis initiation and may lead to bacterial colonization and play as a source for infection transmission to the respiratory system which results in ventilator related pneumonia in patients admitted to the Intensive Care Units (ICUs). Therefore, finding methods to ...

objectives: the purpose of this study was to determine the efficacy of oral sucralfate suspension (1gr/10ml) in the treatment of recurrent aphthous stomatitis (ras). materials and methods: fifty-five patients with oral aphthae were included in this randomized, double-blind, placebo-controlled clinical trial conducted in the department of oral medicine, school of dentistry, mashhad university of...

The object of the present work was formulation and in vitro evaluation of 5-Fluorouracil nanoparticles incorporated in sucralfate suspension as drug delivery system. Sucralfate acts as the cytoproytective agent and carry the antineoplastic drug loaded nanoparticles to the carcinoma site in the g .i.t which will protect and alleviate the carcinoma. 5-Fluorouracil nanoparticles were prepared by n...

acidic ph of stomach, which is a normal physiological barrier against bacterial overgrowth, would increase by stress ulcer prophylaxis initiation and may lead to bacterial colonization and play as a source for infection transmission to the respiratory system which results in ventilator related pneumonia in patients admitted to the intensive care units (icus). therefore, finding methods to decre...