Epidemiological evidence links pulmonary arterial hypertension (PAH) with thyroid disease, but a mechanistic explanation for this association is lacking. Because a central hallmark of vascular remodelling in pulmonary hypertension is lumen obliteration by endothelial cell growth and because thyroid hormones are known to be angiogenic, we hypothesised that thyroid hormones play a role in the con...

BACKGROUND Surgery for Graves' disease may be performed with the intent of preserving thyroid function (subtotal thyroidectomy) or ablating thyroid function (total thyroidectomy). This study examines the evolving practice in a specialist endocrine surgical unit. METHOD Longitudinal cohort study of patients undergoing surgery for Graves' disease between 1986 and 2008. Outcome measures were thy...

Objective The extent of surgery for differentiated thyroid carcinoma (papillary and follicular) is still controversial, extending from simple lobectomy to extensive total thyroidectomy. The objective of this study was to assess the outcome of different types of thyroidectomy in patients with differentiated thyroid carcinoma (DTC). Methods The extent of primary surgical therapy for 428 patients ...

thyroid tissue located within the upper airway has received only sparse attention in the english literature. aberrant benign thyroid masses may present as either an unrelated autopsy finding or with symptoms such as dyspnea, hemoptysis or adult -onset asthma. there is no place for medical management in the therapy of these lesions, although the appropriate surgical procedure is not clearly esta...

PURPOSE The possibility of altered response to nondepolarizing muscle relaxants in hyperthyroidism patients has not been documented. The present study was conducted to observe the onset and duration of rocuronium induced neuromuscular blockade in hyperthyroidism patients. METHODS Eighteen hyperthyroidism patients undergoing subtotal thyroidectomy (H group) and eighteen euthyroidism patients u...

The use of surgical drains in patients undergoing thyroid surgery is standard surgical teaching. Life-threatening complications, arising from post-operative haematomas, mandates their utilization. There is increasing evidence to suggest that this is an outdated practice. This paper determines whether thyroid surgery can be safely performed without the routine use of drains. A retrospective revi...