The novel derivatives of thieno[3',2':4,5]thieno[2,3-c]quinolones 6a, 6b, 7, 10a and 10b were synthesized in multistep synthesis starting from thiophene-3-carboxaldehyde and malonic acid reacting in aldol condensation or from 3-bromothiophenes or methyl 4-bromothiophene-2-carboxylate reacting in Heck reaction. They resulted in corresponding substituted thienylacrylic acids 3a-c, which were cycl...

Enrofloxacin is a member of the family of 6-fluoro-7-piperazinyl-4-quinolones.1 This antibiotic is highly lipophilic, and the addition of a carboxic acid and a tertiary amine contributes to the amphoteric properties of enrofloxacin.2 Enrofloxacin is bactericidal and has excellent activity against both Gram-positive and Gram-negative pathogens.1,3 This antibiotic has also been used to control ce...

chemically, may be regarded as weak substituted heterocyclic amino acids. These drugs primarily find use in the treatment of urinary and respiratory infections. Fluoroquinolones exhibit strong activity against Gram-negative and some Gram-positive bacteria, though many anaerobic strains are resistant. Fleroxacin and moxifloxacin are fluoroquinolone family members which belong to 2nd and 4th gene...

Design, synthesis, anticancer, docking, and in silico assessment for 8-piperazinyl caffeinyl-triazolylmethyl hybrid conjugates are explained. These compounds have satisfactory activities against melanoma breast cancer cell lines.

Mycobacterium leprae, the causative agent of leprosy, is noncultivable in vitro; therefore, evaluation of antibiotic activity against M. leprae relies mainly upon the mouse footpad system, which requires at least 12 months before the results become available. We have developed an in vitro assay for studying the activities of quinolones against the DNA gyrase of M. leprae. We overexpressed in Es...