Introduction: Portulaca oleracea is a common plant used in South Indian culinary; recently there is increase in research publication on various biological activities of the medicinal herb. The safety of the medicinal herb well accounted by its widespread accepted use of natives yet scientific evaluation on the safety of the herb is not reported. Aim To scientifically evaluate the toxicity profi...

Plumeria alba Linn (Apocynaceae) is used in Togolese traditional medicine to treat diabetes mellitus and wounds. The present investigation was carried out to evaluate the toxicity of hydroalcoholic extract of Plumeria alba roots in Sprague Dawley rats. The acute toxicity test was conducted by administering orally dose of 5 g/Kg. General behavior and mortality were examined for up to 14 days. Th...

objective: pinus eldarica (p. eldarica) is one of the most common pines in iran which has various bioactive constituents and different uses in traditional medicine. since there is no documented evidence for p. eldarica safety, the acute and sub-acute oral toxicities of hydroalcoholic extract of p. eldarica bark were investigated in male and female wistar rats in this study. materials and method...

ABSTRACT Introduction: Impaired wound healing is a major concern specially in diabetic patients due to unregulated chronic hyperglycemia which further may lead to ulcer, gangrene, and its complications, therefore the development of natural, nontoxic and effective agent is required. we carried out an acute and subacute oral toxicity study on the Cyperus Papyrus (CP) ash in Wistar albino rats. C...

Saffron (Crocus sativus L.) has been considered as a medicinal plant since ancient times and also widely used as food additive for its color, taste and odor. The pharmacological properties of saffron and its main constituents, crocin and safranal have been evaluated using different in vivo and in vitro models. Additionally, other lines of studies have found toxicological effects of saffron.  Ho...

BACKGROUND The aim of this work was to determine the technical feasibility and safety of extended-field radiotherapy (EF), performed by Helical TomoTherapy, in patients with positive pelvic and/or para-aortic nodes. Dosimetric data were collected and acute and sub-acute toxicities of the upper abdominal organs at risk (OAR) were evaluated. METHODS Twenty-nine patients suitable for EF irradiat...

in iranian folk medicine, especially in west of the country, the aromatic water of rheum ribes has been used for several purposes such as fever reduction.  despite the widespread use of this plant as food or as a medicinal plant, there is still lack of information on its toxicity profile.                                                                in the present study we aimed to evaluate th...

The majority of patients affected with nitrofurantoin pulmonary toxicity are elderly women [1]. The proposed mechanism of toxicity is either idiosyncratic oxydant-mediated tissue injury by nitrofurantoin metabolites causing depletion of cellular glutathione (chronic form) or by immunological response induced by nitrofurantoin metabolites acting as heptanes and resulting a hypersensitivity react...

Drugs that have antimicrobial, anti-inflammatory and wound-healing effects deserve special attention, sodium-containing drugs are one of them, which is why they used in veterinary medicine.
 The article presents the results experimental studies to study sub-acute toxicity drugs: known – glycetinate 2%, its analogues ovocid 3%, potassium-sodium 1.5% (Na / K, 1.5%).
 was carried out by ...

The acute and sub-acute toxicity of safranal were studied in rat and mice within 2 and 21 days after exposure, respectively. For subacute toxicity, changes in weight as well as biochemical, hematological and pathological parameters were studied. The intraperitoneal LD50 values of safranal were 1.48 mL/kg in male mice, 1.88 mL/kg in female mice and 1.50 mL/kg in male rats. Oral LD50 values were ...