BACKGROUND Strychnos potatorum Linn (Loganiaceae) is a moderate sized tree found in southern and central parts of India, Sri Lanka and Burma. In traditional system of medicine, Strychnos potatorum Linn seeds were used for various ailments including inflammation, diabetes etc. To investigate the folkloric use of the seeds the present study was carried out on Freund's adjuvant induced arthritic r...

An enantioselective total synthesis of the Strychnos alkaloid (+)-minfiensine has been accomplished. Prominent features of this synthesis include (i) a new enantioselective organocatalytic Diels-Alder/amine cyclization sequence to build the central tetracyclic pyrroloindoline framework in four steps from commercial materials and (ii) a 6-exo-dig radical cyclization to forge the final piperidiny...

The in vitro antimalarial activities of 46 alkaloids and extracts from Strychnos species were evaluated. Two types of quasidimeric alkaloids exhibit high and selective activities against Plasmodium. Strychnopentamine and isostrychnopentamine were active against chloroquine-sensitive and -resistant strains (50% inhibitory concentration [IC(50)] approximately 0.15 microM), while dihydrousambarens...

Abstract Loganiaceae is a member of the Gentianales order and comprises about 460 species in 16 genera, being mainly distributed tropical regions world. The Brazilian Neotropical region one centers diversity for two richest genera Loganiaceae, Spigelia Strychnos, justifying floristic efforts to better understand family this region. This study aims update taxonomic knowledge state Pernambuco, No...

The larvicidal activity of hexane, chloroform and ethyl acetate leaf extracts of Strychnos nuxvomica against the third instar larvae of Culex quinquefasciatus was studied. The ethyl acetate leaf extract was found to be the effective larvicide with LC value of 222.28 and 146.99 ppm after 24 and 48 hours. The results indicate 50 promising larvicidal activity against Culex quinquefasciatus. Furthe...

This study aimed to evaluate the sleep modulating properties of Strychnos spinosa and innocua fruits in Swiss albino mice. The depressant effect extracts on central nervous system was studied using a diazepam-induced model mice were divided into four groups six each. test received at doses 250, 500, 1000 mg/kg body weight intraperitoneally. In contrast, control group distilled water 10 ml/kg. D...